42093-97-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Piperidinobenzoic acid is used as a key intermediate for the synthesis of various drugs, including antihistamines, antidepressants, and antipsychotic medications. Its unique structure contributes to the development of these therapeutic agents, enhancing their efficacy and pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Piperidinobenzoic acid is utilized in the production of various compounds that aid in crop protection and enhancement of agricultural yields. Its role in this industry is crucial for the development of effective and safe agrochemicals.
Used in Organic Dyes Manufacturing:
2-Piperidinobenzoic acid is also employed in the manufacturing of organic dyes, where its chemical properties contribute to the creation of vibrant and stable colorants for various applications, including textiles, plastics, and printing inks.
Used in Chemical Research and Development:
As a versatile compound, 2-Piperidinobenzoic acid is used in research and development for the creation of new derivatives with specific properties. This allows for the exploration of novel applications and advancements in various fields, including medicine, materials science, and environmental chemistry.
Safety Precautions:
It is important to handle and store 2-Piperidinobenzoic acid with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure. Proper safety measures, including the use of personal protective equipment and adherence to storage guidelines, should be followed to minimize potential health risks.

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 192817-76-8 ethyl 2-piperidinobenzoate 
• 443-26-5 2-fluoro-benzoic acid ethyl ester 
• 110-89-4 piperidine 
• 124-38-9 carbon dioxide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 72752-52-4 2-(piperidin-1-yl)benzonitrile 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 168162-97-8 methyl (Z)-[4,4-difluoro-1-[4-(2piperidinobenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate 
• 1078711-99-5 N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-piperidin-1-ylbenzamide 
• 81215-42-1 2-(piperidin-1-yl)benzoic acid methyl ester 

Relevant academic research and scientific papers

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.

Direct access to anthranilic acid derivatives via CO2 incorporation reaction using arynes

(Chemical Equation Presented) CO2 was found to be directly convertible into anthranilic acid derivatives of great synthetic value through a three-component coupling using arynes and amines. Zwitterions arising from nucleophilic attack of amines to arynes serve as key intermediates in the coupling.

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition

In our previous study on discovering novel types of CCR3 antagonists, we found a fluoronaphthalene derivative (1) that exhibited potent CCR3 inhibitory activity with an IC50 value of 20 nM. However, compound 1 also inhibited human cytochrome P450 2D6 (CYP2D6) with an IC50 value of 400 nM. In order to reduce its CYP2D6 inhibitory activity, we performed further systematic structural modifications on 1. In particular, we focused on reducing the number of lipophilic moieties in the biphenyl part of 1, using C log D7.4 values as the reference index of lipophilicity. This research led to the identification of N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide 1-oxide (30) which showed comparable CCR3 inhibitory activity (IC50 = 23 nM) with much reduced CYP2D6 inhibitory activity (IC50 = 29,000 nM) compared with 1.