421-36-3

Usage

Uses

Used in Refrigeration Industry:
1,2-Dibromo-1-chloro-2,2-difluoroethane is used as a refrigerant for its thermodynamic properties that make it suitable for cooling systems. Its performance in refrigeration applications is attributed to its high latent heat of vaporization and favorable enthalpy of fusion.
Used in Chemical Synthesis:
In the chemical industry, 1,2-dibromo-1-chloro-2,2-difluoroethane serves as a precursor for the production of fluoropolymers. These polymers are valued for their exceptional chemical resistance, thermal stability, and non-stick properties, making them ideal for applications such as coatings, linings, and electrical insulation.
Used in Firefighting Equipment:
Known by its trade name Halon 1211, 1,2-dibromo-1-chloro-2,2-difluoroethane is used as a fire extinguishing agent in specific applications. Its effectiveness in suppressing fires is due to its ability to interrupt the chemical reactions involved in combustion without leaving any residue.
However, the use of 1,2-dibromo-1-chloro-2,2-difluoroethane as a fire suppressant has been on the decline due to its ozone-depleting properties and its contribution to global warming. As a result, it is now considered an environmental hazard and is subject to stringent regulatory control to mitigate its impact on the atmosphere and climate.

InChI:InChI=1/C2HBr2ClF2/c3-1(5)2(4,6)7/h1H

Upstream product

• 359-10-4 1-Chloro-2,2-difluoroethene 
• 758-24-7 1-Bromo-1-chloro-2,2-difluoroethylene 

Downstream Products

• 758-24-7 1-Bromo-1-chloro-2,2-difluoroethylene 
• 3832-48-2 bromodifluoroacetyl chloride 

Relevant academic research and scientific papers

Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics

The inhaled anesthetics are low affinity volatile compounds whose mechanism of action remains unclear, in part due to the difficulty of determining their binding targets. Photolabeling may help resolve this difficulty, and thus we have synthesized six compounds (four previously unreported) with structural and physical similarity to halothane (1-bromo-1-chloro-2,2,2-trifluoroethane), a commonly used clinical anesthetic. These compounds incorporate either a diazo, diazirine, or azido group to provide photolability in the long-UV range and to provide a highly reactive photolysis product. While several of the compounds have immobilizing activity in tadpoles, it is complicated by either toxicity or very low potency. One compound however, a halogenated three-carbon diazirine 4, is a potent anesthetic, is apparently nontoxic, potentiates GABAA Cl- currents, and stabilizes serum albumin, all of which are features of halothane. When tagged with radioactivity, this compound should serve as a reasonable probe of haloalkane anesthetic binding targets and sites.

A two-fluorine bromine acetate preparation method (by machine translation)

The invention provides a two-fluorine bromine acetate preparation method, comprises the following steps: (1) in order to CF2 X - CHCl2 As raw materials, through the dehydrochlorination cancels out the reaction, bromine addition reaction CF2 Br - CClXBr, wherein X is H or Cl; (2) step (1) in the CF2 Br - CClXBr optical oxidation or with sulfur trioxide oxidation reaction, reaction to obtain the CF2 Br - COCl; (3) the step (2) in the CF2 Br - COCl alcohol in the esterification reaction, after separation, distillation, thus obtaining the product 2, 2 - difluoro - 2 - [...] ester. The invention two fluorine bromine acetate preparation method, so that the 1, 1 - difluoro - 2, 2 - dichloroethane or 1, 1 - difluoro - 1, 2, 2 - trichloroethane two by-product that is utilized, reduce their pollution of the environment, but also the production two fluorine bromines acetate process is environment-friendly, two fluorine bromines acetate yield and safety are relatively high. (by machine translation)

Green synthesis method of ethyl bromodifluoroacetate

The invention provides a green synthesis method of ethyl bromodifluoroacetate. According to the method, 1,1-difluoro-1,2-dichloroethane is used as a starting material; elimination reaction is performed to obtain 1,1-difluoro-2-chloroethylene; the 1,1-difluoro-2-chloroethylene and bromine are subjected to addition to obtain 1,1-difluoro-1,2-dibromo-2-chloroethane; then, the elimination reaction is performed to obtain a 1,1-difluoro-2-bromine-2-chloroethylene; then, the 1,1-difluoro-2-bromine-2-chloroethylene and the bromine are subjected to addition to obtain 1,1-difluoro-1,2,2-tribromo-2-chloroethane; then, sulfur trioxide is used for oxidizing the 1,1-difluoro-1,2,2-tribromo-2-chloroethane; 1,1-difluoro-1-bromoacetyl chloride is obtained; finally, the 1,1-difluoro-1-bromoacetyl chloride and ethyl alcohol are esterified to obtain 2,2-difluoro-2-ethyl bromoacetate. The synthesis method has the advantages that the problems of recovery and utilization of waste materials of 1,1-difluoro-1,2-dichloroethane (R132b) are solved; no organic solvents are used in the reaction process; the oxidation step uses SO3 for oxidation; high temperature and high pressure or concentrated sulfuric acid is not needed; the safety is enhanced; the discharging of waste acid is reduced; the green production requirement is met; the product yield is relatively high; the green synthesis method is suitable for industrial production.

Practical preparation of potentially anesthetic fluorinated ethyl methyl ethers by means of bromine trifluoride and other methods

Synthetic methods, especially those that use bromine trifluoride as a fluorinating agent, are described for the preparation of a number of fluorinated ethyl methyl ethers in good yield and high purity. In all cases, medium-scale syntheses (8-22g) of potentially anesthetic compounds have been accomplished. The compounds are of sufficient purity (>99%) for biological evaluation.