421-36-3

Basic information

• Product Name: 1,2-DIBROMO-1-CHLORO-2,2-DIFLUOROETHANE
• Synonyms: 1,2-dibromo-2-chloro-1,1-difluoroethane;ethane,1,2-dibromo-2-chloro-1,1-difluoro-;1-CHLORO-1,2-DIBROMO-2,2-DIFLUOROETHANE;1,2-DIBROMO-1-CHLORO-2,2-DIFLUOROETHANE;1-Chloro-1,2-dibromo-2,2-difluoroethane97%
• CAS NO: 421-36-3
• Molecular Formula: C₂HBr₂ClF₂
• Molecular Weight: 258.29
• Mol File: 421-36-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 120°C
• Flash Point: 24.8°C
• Appearance: /
• Density: 2.9850 (rough estimate)
• Vapor Pressure: 20.8mmHg at 25°C
• Refractive Index: 1.6020 (estimate)
• CAS DataBase Reference: 1,2-DIBROMO-1-CHLORO-2,2-DIFLUOROETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIBROMO-1-CHLORO-2,2-DIFLUOROETHANE(421-36-3)
• EPA Substance Registry System: 1,2-DIBROMO-1-CHLORO-2,2-DIFLUOROETHANE(421-36-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 421-36-3(Hazardous Substances Data)

Usage

General Description

1,2-Dibromo-1-chloro-2,2-difluoroethane is a chemical compound with the molecular formula C2H2Br2ClF2. It is a colorless liquid with a sweet odor, and it is commonly used as a refrigerant and as a precursor for the production of fluoropolymers. It is also known by its trade name Halon 1211 and is used as a fire extinguishing agent in some applications. However, its use as a fire suppressant has been decreasing due to its ozone-depleting properties and its contribution to global warming. It is also considered to be a potential environmental hazard and is subject to strict regulatory control.

InChI:InChI=1/C2HBr2ClF2/c3-1(5)2(4,6)7/h1H

Upstream product

• 758-24-7 1-Bromo-1-chloro-2,2-difluoroethylene 
• 359-10-4 1-Chloro-2,2-difluoroethene 

Downstream Products

• 3832-48-2 bromodifluoroacetyl chloride 
• 758-24-7 1-Bromo-1-chloro-2,2-difluoroethylene 

Relevant articles and documents

Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics

The inhaled anesthetics are low affinity volatile compounds whose mechanism of action remains unclear, in part due to the difficulty of determining their binding targets. Photolabeling may help resolve this difficulty, and thus we have synthesized six compounds (four previously unreported) with structural and physical similarity to halothane (1-bromo-1-chloro-2,2,2-trifluoroethane), a commonly used clinical anesthetic. These compounds incorporate either a diazo, diazirine, or azido group to provide photolability in the long-UV range and to provide a highly reactive photolysis product. While several of the compounds have immobilizing activity in tadpoles, it is complicated by either toxicity or very low potency. One compound however, a halogenated three-carbon diazirine 4, is a potent anesthetic, is apparently nontoxic, potentiates GABAA Cl- currents, and stabilizes serum albumin, all of which are features of halothane. When tagged with radioactivity, this compound should serve as a reasonable probe of haloalkane anesthetic binding targets and sites.

Green synthesis method of ethyl bromodifluoroacetate

The invention provides a green synthesis method of ethyl bromodifluoroacetate. According to the method, 1,1-difluoro-1,2-dichloroethane is used as a starting material; elimination reaction is performed to obtain 1,1-difluoro-2-chloroethylene; the 1,1-difluoro-2-chloroethylene and bromine are subjected to addition to obtain 1,1-difluoro-1,2-dibromo-2-chloroethane; then, the elimination reaction is performed to obtain a 1,1-difluoro-2-bromine-2-chloroethylene; then, the 1,1-difluoro-2-bromine-2-chloroethylene and the bromine are subjected to addition to obtain 1,1-difluoro-1,2,2-tribromo-2-chloroethane; then, sulfur trioxide is used for oxidizing the 1,1-difluoro-1,2,2-tribromo-2-chloroethane; 1,1-difluoro-1-bromoacetyl chloride is obtained; finally, the 1,1-difluoro-1-bromoacetyl chloride and ethyl alcohol are esterified to obtain 2,2-difluoro-2-ethyl bromoacetate. The synthesis method has the advantages that the problems of recovery and utilization of waste materials of 1,1-difluoro-1,2-dichloroethane (R132b) are solved; no organic solvents are used in the reaction process; the oxidation step uses SO3 for oxidation; high temperature and high pressure or concentrated sulfuric acid is not needed; the safety is enhanced; the discharging of waste acid is reduced; the green production requirement is met; the product yield is relatively high; the green synthesis method is suitable for industrial production.