42116-86-9

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 603-35-0 triphenylphosphine 
• 119-67-5 o-carboxybenzaldehyde 
• 6940-49-4 3-Bromophthalide 

Downstream Products

• 127223-31-8 3-<3-(phenyl)propylidene>phthalide 
• 127223-32-9 3-<3-(3-methoxyphenyl)propylidene>phthalide 
• 105279-23-0 (2Z) 2-(1-(4-nitrophenyl)methylene)benzofuran-3(2H)-one 
• 791-28-6 Triphenylphosphine oxide 
• 4767-56-0 (Z)-3-benzylidenephthalide 
• 171513-93-2 (3E)-3-[(E)-3-phenylallylidene]-(3H)-isobenzofuran-1-one 
• 114259-22-2 o-<(p-nitrophenyl)acetyl>benzoic acid 
• 1217472-04-2 1-(4-benzyloxybenzyl)-4-chlorophthalazine 
• 1196046-93-1 3-(5-chloro-2-nitrobenzylidene)-2-benzofuran-1(3H)-one 
• 127223-36-3 2,2'-Bis-[2-(3-methoxy-phenyl)-ethyl]-[2,2']biindenyl-1,3,1',3'-tetraone 
• 127223-29-4 2-<2-(3-methoxyphenyl)ethyl>-1,3-indanedione 
• 127223-35-2 2,3-dihydro-7-benzyloxy-1H-indene-1-spiro-2'-(2H-indene)-1',3'-dione 
• 127223-30-7 2-<2-(3-benzyloxyphenyl)ethyl>-1,3-indanedione 
• 127223-34-1 2,2'-Diphenethyl-[2,2']biindenyl-1,3,1',3'-tetraone 

Relevant academic research and scientific papers

NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

The present invention provides novel poly(ADP-ribose) polymerase (PARP) inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods for the treatment, prevention and/or amelioration of PARP mediated diseases or disorders using them. In particular, the compounds described herein are useful for the treatment of carcinoma of the breast, ovarian cancer, carcinoma of the liver, carcinoma of the lung, small cell lung cancer, esophageal cancer, gall bladder cancer, pancreatic cancer and stomach cancer.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A methyl group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximised potencies and residence times.

SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION

Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof. R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2' is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofuryhnethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5', R6, R6', R7, R7' are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.

Experimental and theoretical study on the photophysical properties of a pyrrolyl-isoxazole derivative

The paper aims at characterizing the excited state of a pyrrolyl-isoxazole derivative containing, apart from these two fragments with electron donor (D) - pyrrolyl - and acceptor (A) - isoxazole - character, a third one - methylenephthalydyl - having also an A character. They are single bonded in an A-D-A arrangement. It is shown that the presence of the second A fragment in the molecule modifies the photophysical properties comparing to D-A pyrrolyl-isoxazole derivatives: lower Stokes shift, band width practically independent on the polarity of the solvent, linear dependence of the Stokes shift on the solvent polarity function. The spectral study of the inclusion complex of the studied compound in β-cyclodextrin reveals a decrease in the emission intensity in the presence of cyclodextrin. These experimental findings are consistent with the lack of a twisted intramolecular charge transfer (TICT) excited state, which in turn is present for pyrrolyl-isoxazole derivatives of the D-A type. The lack of a TICT state is further ascertained by theoretical calculations of sections through the potential energy surfaces along both possible A to D rotation dihedrals. The stable conformations are quasiplanar, while the orthogonal conformations are unstable.