92495-98-2

Upstream product

• 922529-76-8 (2-bromophenyl)(cyclohexyl)methanone 
• 1864-94-4 phenyl formate 
• 6940-49-4 3-Bromophthalide 
• 61260-15-9 dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate 
• 108-94-1 cyclohexanone 
• 42116-86-9 (3-oxo-1,3-dihydro-2-benzofuran-1-yl)(triphenyl)phosphonium bromide 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by using phenyl formate as a carbon monoxide source

A simple and efficient palladium-catalyzed intramolecular carbonylative synthesis of isocoumarins and phthalides from the easily available starting materials by employing phenyl formate as a CO surrogate has been achieved. The approach affords target compounds in good to excellent yields with the advantages of lower toxicity, milder conditions, easy operation and wide functional group tolerance.

Palladium-catalyzed synthesis of isocoumarins and phthalides via tert -butyl isocyanide insertion

A novel and highly efficient strategy for the synthesis of isocoumarins and phthalides through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. This process, providing one of the simplest methods for the synthesis of this class of valuable lactones, involves two steps including cyclization reaction and simple acid hydrolysis. The methodology is tolerant of a wide range of substrates and applicable to library synthesis.

Wittig-Horner reaction of dimethyl phthalide-3-phosphonates with ketones: Synthesis of 3-ylidenephthalides and their conversion to 2,2-disubstituted indan-1,3-diones including spirocyclic compounds

The Wittig-Horner reaction of dimethyl phthalide-3-phosphonates with various ketones was investigated under the conditions: lithium bis(trimethylsilyl)amide (LHMDS) or sodium hydride in tetrahydrofuran, and cesium carbonate in isopropyl alcohol. The sequential treatment of the 3-ylidenephthalides with diisobutylaluminium hydride (DIBAL-H) and pyridinium dichromate (PDC) afforded 2,2-disubstituted indan-1,3-dione derivatives in modest to high overall yields.