4212-74-2

Basic information

• Product Name: Benzene, 2,4-dimethyl-1-(phenylsulfonyl)-
• CAS NO: 4212-74-2
• Molecular Formula: C14H14O2S
• Molecular Weight: 246.33
• Mol File: 4212-74-2.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 2,4-dimethyl-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2,4-dimethyl-1-(phenylsulfonyl)-(4212-74-2)
• EPA Substance Registry System: Benzene, 2,4-dimethyl-1-(phenylsulfonyl)-(4212-74-2)

Safety Data

• Hazardous Substances Data: 4212-74-2(Hazardous Substances Data)

Upstream product

• 609-60-9 2,4-dimethylbenzenesulfonyl chloride 
• 108-38-3 m-xylene 
• 98-09-9 benzenesulfonyl chloride 
• 1019453-85-0 2-(2,4-dimethylphenylsulphanyl)benzeneamine 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 
• 13616-82-5 2,4-dimethyl-thiophenol 
• 71-43-2 benzene 
• 1610527-49-5 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene 
• 933671-83-1 1-bromo-2-iodo-3,5-dimethylbenzene 
• 88-73-3 2-Chloronitrobenzene 
• 41825-73-4 2-bromo-4,6-dimethylaniline 

Downstream Products

• 109966-48-5 2-benzyl-4-methyl-benzenesulfinic acid 

Relevant articles and documents

Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Highly selective catalytic Friedel-Crafts sulfonylation of aromatic compounds using a FeCl3-based ionic liquid

Friedel-Crafts sulfonylation of aromatic compounds was carried out using FeCl3-based ionic liquid. These liquids serve as efficient media as well as Lewis acid catalyst.

A practical and efficient method for the preparation of aromatic sulfones by the reaction of aryl sulfonyl chlorides with arenes catalysed by Fe(OH) 3

Fe (OH)3 catalyses Friedel-Crafts sulfonylation of arenes with aryl sulfonyl chlorides to obtain the corresponding diaryl sulfones in good yields.

An efficient and convenient method for the synthesis of aromatic sulfones catalysed by ZrO2/S2O82- solid superacid

A manipulatively simple and rapid procedure for the synthesis of diaryl sulfones from arylsulfonyl chlorides with aromatic compounds is described; the reaction is conducted under Friedel-Crafts conditions in the absence of solvent using ZrO2/S2O82- as catalyst in 78-93% yields.

An efficient method for aromatic Friedel-Crafts alkylation, acylation, benzoylation, and sulfonylation reactions

Aromatic electrophilic substitution reactions such as alkylation, acylation, benzoylation, and sulfonylation were studied in the presence of a catalytic amount of Cu(OTf)2 and Sn(OTf)2. Cu(OTf)2 was very efficient for alkylation, acylation, and benzoylation reactions. However, in case of sulfonylation reactions, Sn(OTf)2 gave better results.

Acylation and related reactions under microwaves. 4. Sulfonylation reactions of aromatics

Solvent-free sulfonylation of benzene and its activated or deactivated derivatives were carried out under microwave (MW) irradiation and a catalytic amount of iron(III) chloride, which, under these conditions, is more, active than other metallic salts. With more reactive and/or nonvolatile reagents (anisole, xylenes, mesitylene) expeditious conditions (short reaction time at constant MW power without control of the temperature) were used. With less reactive and/or low-boiling reagents (benzene, toluene, halobenzenes), the rise in temperature and the increase of reaction time were controlled either by sequential MW irradiation or by a temperature order. It was shown that MWs cause preferential interactions with polar species present in the reaction, especially the aryl sulfone and its FeCl3-complexed form. A MW nonthermal effect was not observed when identical temperature gradients were produced by classical heating and MW irradiation, and if reaction temperature was strictly controlled.

An efficient and novel method for the synthesis of aromatic sulfones under solvent - Free conditions

A manipulative simple and rapid reaction of arensulfonyl chloride with aromatic hydrocarbons is described. The reaction is conducted under Friedel-Crafts conditions in the absences of solvent using aluminium chloride as catalysts.

Organic reactions under solid-state conditions

Manipulatively simple and rapid methods are described for the synthesis of: chiral sulfinate esters from sulfonyl chlorides and sufonic acids; aldehydes and ketones from oximes, alcohols, hydrozones; sulfoxides from sulfides; and disulfides from thiols. The chemical yields are good to excellent and diastereoselectivity is high.

Fe(III) exchanged montmorillonite: A mild and ecofriendly catalyst for sulfonylation of aromatics

Fe(III) exchanged montmorillonite clay catalyses Friedel-Crafts sulfonylation of arenes with arylsulfonyl chlorides to obtain the corresponding sulfones in excellent yields.