42149-74-6Relevant academic research and scientific papers
Preparation method of chloro-aliphatic ether
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Paragraph 0099; 0112; 0117-0118; 0124; 0129; 0130, (2017/10/13)
The invention discloses a preparation method of chloro-aliphatic ether, and aims to solve the problems that when 2-propoxy-dichloroethane is synthesized by adopting an existing method, a large amount of sulphur dioxide is produced and the amount of wastewater is large, solid waste pollution can be produced if a phase catalyst is recycled and applied mechanically, and when triphosgene is used as a chlorating agent, the price of the triphosgene is expensive so that the triphosgene is not suitable for large-scale industrial production. The method comprises the following steps: 1) carrying out reaction on a compound shown in a formula (I) and carbonyl chloride to prepare a compound shown in a formula (II); (2) carrying out decarboxylic reaction on the compound shown in the formula (II) to prepare a compound shown in a formula (III). According to the preparation method disclosed by the invention, a brand-new route for preparing the chloro-aliphatic ether is provided, so that the yield of the chloro-aliphatic ether is high, and the production cost can be effectively reduced; moreover, HC1, CO2 and a small amount of high-salinity wastewater only can be produced, so that three wastes are little, the environment protection is achieved, and the environment protection cost is low; in addition, the method also can be applied to preparation of multi-structure chloro-aliphatic ether, has a higher application value and wide application prospect, and is worthy of massively popularized and applied.
Preparation method of chloroformate derivatives, and application of preparation method
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Paragraph 0106; 0108-0115; 0117-0119; 0120-0125, (2017/11/18)
The invention discloses a preparation method of chloroformate derivatives, and application of the preparation method, belonging to the field of chemical synthesis. The invention aims at providing a new preparation method, which can meet the needs of industrial production, of the chloroformate derivatives. The chloroformate derivatives prepared by the method are as shown in a formula (II) below; the method comprises the following step: enabling compounds as shown in a formula (I) to react with phosgene so as to obtain the compounds shown in the formula (II), wherein a reaction equation is shown in the description. The preparation method provided by the invention has the advantages of simple and convenient production, safety and the like; the prepared product has higher product purity and reaction yield; furthermore, the treatment of three wastes is simple and convenient; therefore, the preparation method has higher application value and wide application prospect and is worth large-scale popularization and application.
Production method of 2-propoxyethyl chloride
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Paragraph 0012; 0017-0032, (2017/08/30)
The invention relates to a production method of 2-propoxyethyl chloride and belongs to the technical field of fine chemical intermediate organic synthesis. The synthesis process comprises the following steps: preparing a crude product by taking ethylene glycol monopropyl ether and excessive sulfoxide chloride as main raw materials and adopting an efficient catalyst through heating and heat preservation, wherein the reaction rate is controlled by dropwise adding sulfoxide chloride; and performing neutralization, hydrolysis, and liquid separation after standingto obtain 2-propoxyethyl chloride. Compared with the existing process, the synthesis process has the advantages that the catalyst has higher catalytic efficiency and is cheap and easily available; the technological process is simple and convenient; the catalyst used in the existing process and hydrochloric acid in the crude product form a complex easily, so that the product has precipitates and the product yield is influenced; and the crude product prepared by the catalyst is clear and transparent, the product can be obtained without water washing, the quality is stable, the product content reaches above 99.5 percent, the yield is more than 99.0 percent, the production cost is lower, and the synthesis process is particularly suitable for industrialized production.
Synthesis process of 2-propoxyethyl chloride
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Paragraph 0012; 0017-0032, (2017/08/30)
The invention relates to a synthesis process of 2-propoxyethyl chloride and belongs to the technical field of fine chemical intermediate organic synthesis. The synthesis process comprises the following steps: preparing a crude product by taking ethylene glycol monopropyl ether and excessive sulfoxide chloride as main raw materials and adopting an efficient catalyst through heating and heat preservation, wherein the reaction rate is controlled by dropwise adding sulfoxide chloride; and performing neutralization, hydrolysis, and liquid separation after standing to obtain 2-propoxyethyl chloride. Compared with the existing process, the synthesis process has the advantages that the catalyst has higher catalytic efficiency; and the existing process needs 0.1 to 0.2 mol of excessive sulfoxide chloride, but the catalyst only needs 0.01 mol of excessive sulfoxide chloride, so fewer waste water and waste residues are generated when the crude product is treated, the product content reaches above 99.5 percent, the yield is more than 99.0 percent, the production cost is lower, and the synthesis process is suitable for industrialized production.
Preparation process of 2-propoxy chloroethane
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Paragraph 0016; 0017; 0018; 0019; 0020; 0021; 0022-0031, (2017/09/02)
The invention relates to a preparation process of 2-propoxy chloroethane and belongs to the technical field of organic synthesis of fine chemical intermediates. The synthetic process comprises the following steps: by taking ethylene glycol monopropyl ether and excess thionyl chloride as raw materials and adopting a high efficiency composite catalyst, controlling the reaction rate through dropwise adding the thionyl chloride, raising the temperature and preserving the temperature to obtain a crude product, neutralizing, hydrolyzing, standing and layering to obtain the 2-propoxy chloroethane. Compared with the prior art, the preparation process disclosed by the invention has the advantages that the catalyst is higher in catalytic efficiency, low in price and easy to get; the process is simple, safe and reliable; the product is high in yield and stable in quality; the product content is up to above 99.0%; the yield is greater than 98.5%; catalysts used in the prior art easily react with little hydrochloric acid contained in the product to form complex salt which is a precipitate in the 2-propoxy chloroethane and then the product quality is influenced; and the preparation process is particularly suitable for industrial production.
Method for synthesizing 2-chloroethyl-propylether
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Paragraph 0036-0038, (2017/03/14)
The invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 2-chloroethyl-propylether. An efficient nucleophilic catalyst is adopted, 2-propoxyethanol and thionyl chloride serve as main raw materials, the reaction speed is strictly controlled by adding thionyl chloride dropwise, and then a crude product is obtained after heating and heat preserving; after cooling, solid alkali is directly added to decompose excessive thionyl chloride and neutralize thionyl chloride; finally, 2-chloroethyl-propylether is obtained after filtering. The purity reaches 99.5% or above, the yield is larger than 98.8%, and the water content is smaller than 0.1%. Compared with the prior art, no waste water is generated, the purity and the yield are high, water content is low, and the method is economical, environmentally friendly and suitable for industrial production.
Preparation method of chloroethyl-n-propylether
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Paragraph 0009; 0036; 0037; 0038, (2016/10/20)
The invention relates to the technical field of organic synthesis and concretely relates to a preparation method of chloroethyl-n-propylether. 2-n-propoxyethanol and thionyl chloride as main raw materials undergo a reaction in the presence of a high-efficiency nucleophilic catalyst, wherein through dropwise addition of thionyl chloride, a reaction rate is strictly controlled, the product is heated and is subjected to thermal insulation to form a crude product, and the crude product is subjected to rectification purification to form chloroethyl-n-propylether. The product has clear and transparent appearance, purity of 99.2% or more, a yield of 98.5% or more and water content of 0.2% or less. Compared with the traditional technology, the preparation method does not produce waste water, realizes recycle of a front cut fraction and kettle bed material produced by rectification and a catalyst, realizes high purity, high yield and low water content and is suitable for industrial production.
Preparation method of 1-(2-chloroethoxy)propane
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Paragraph 0010; 0028; 0029; 0030, (2016/10/27)
The invention belongs to the field of organic synthesis technology, and concretely relates to a preparation method of 1-(2-chloroethoxy)propane. Under the synergistic effect of a plurality of catalysts, 2-propoxyethanol and thionyl chloride are used as main raw materials, reaction rate is controlled by adding thionyl chloride drop by drop, heating and insulation are carried out, and a crude product is obtained; hydrolysis and neutralization are carried out, a mixture is permitted to stand for separation, and 1-(2-chloroethoxy)propane is obtained. Compared with prior art, the catalysts are cheap and easily available, the catalysis efficiency is higher, the process is simple with safety and reliability, the product yield is high, the quality is stable, the product content reaches above 99.0%, the yield is higher than 98.5%, the production cost is low, and the method is especially suitable for industrial production.
Preparation method of 1-(2-chloroethoxy)propane
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Paragraph 0010; 0036; 0037; 0038, (2016/11/24)
The invention belongs to the technical field of organic synthesis and specifically relates to a preparation method of 1-(2-chloroethoxy)propane. By an efficient nucleophilic catalyst, 2-propoxyethanol and thionyl chloride are used as main raw materials, and reaction temperature is strictly controlled by dropwise adding thionyl chloride; after heating and thermal insulation, a crude product is obtained; and after hydrolysis, neutralization and standing for liquid separation, 1-(2-chloroethoxy)propane is obtained. In comparison with traditional technologies, the invention has the following advantages: efficiency of the catalyst is higher; the technological process is safe and reliable; operation is simple; product yield is high; quality is stable; product content reaches 99.0% and above; yield is greater than 98.5%; and production cost is lower. The preparation method of the invention is especially suitable for industrial production.
Synthetic method of 1-(2-chloroethoxy)propane
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Paragraph 0025; 0027; 0028; 0029, (2016/12/12)
The invention belongs to the technical field of organic synthesis and specifically relates to a synthetic method of 1-(2-chloroethoxy)propane. Under the action of a phase-transfer catalyst, 2-propoxyethanol and thionyl chloride are used as main raw materials, and reaction rate is controlled by dropwise adding thionyl chloride; after heating and thermal insulation, a crude product is obtained; and after hydrolysis, neutralization and standing for liquid separation, 1-(2-chloroethoxy)propane is obtained. In comparison with prior art, catalytic efficiency of the catalyst is high, the technological process is simple, safe and reliable, product yield is high, quality is stable, product content reaches 99.0% and above, yield is greater than 98.5%, and production cost is lower. The synthetic method of the invention is especially suitable for industrial production.
