42202-48-2Relevant academic research and scientific papers
An Efficient Synthesis of Dinitrile Derivatives by the Reaction of Oxime Esters or Acid Anhydrides with Cyanotrimethylsilane Catalyzed by La(OiPr)3
Fujii, Akiko,Sakaguchi, Satoshi,Ishii, Yasutaka
, p. 6209 - 6212 (2007/10/03)
The reaction of oxime esters with cyanotrimethylsilane (Me3SiCN) under the influence of a catalytic amount of lanthanide compounds produced α-trimethylsilyloxydinitrile derivatives in excellent yields accompanied with the formation of trimethylsilyl oxime ethers. Among the lanthanoid catalysts examined, La(OiPr)3 was found to be the best catalyst. The reaction seems to proceed through the formation of acyl cyanides as intermediates, followed by the addition of Me3SiCN to them. Additionally, the reaction of acetic anhydride with Me3SiCN catalyzed by La(OiPr)3 gave 1-trimethylsilyloxyethane dinitrile. Thus, various α-trimethylsilyloxydinitriles were synthesized in good yields by allowing oxime esters or acid anhydrides to react with Me3SiCN in the presence of a catalytic amount of La(OiPr)3.
A NEW APPROACH TO ARYLMALONONITRILES
Yamaguchi, Shunro,Araki, Hisashi,Hanafusa, Terukiyo
, p. 685 - 688 (2007/10/02)
Arylmalononitriles were prepared from the corresponding benzoyl chlorides by three reaction steps.Treatment of the starting substances with cyanotrimethylsilane in the presence of pyridine gave dicyanotrimethylsiloxymethylbenzenes, which were transformed
