42205-87-8

Upstream product

• 77924-01-7 N,N-diisopropylnicotinamide 
• 611-74-5 N,N-dimethylbenzamide 
• 77924-05-1 N,N-Diisopropyl-4-pyridinecarboxamide 
• 77923-97-8 N,N-diisopropyl pyridine-2-carboxamide 
• 98-88-4 benzoyl chloride 
• 76467-34-0 hydrobromide salts of N-methylphenacylamine 

Downstream Products

• 495-42-1 (-)-Halostachine 

Relevant academic research and scientific papers

Evidence of an nN(amide) → π*ArInteraction in N-Alkyl- N, N′-diacylhydrazines

1,2-Dibenzoyl-1-tert-butylhydrazine (RH-5849) and related N-alkyl-N,N′-diacylhydrazines are environmentally benign insect growth regulators. Herein, we show that an unusual nN(amide) → π*Ar interaction mediated by a hydrazide amide nitrogen atom plays a crucial role in stabilizing their biologically active trans-cis (t-c) rotameric conformations. We provide NMR and IR spectroscopic evidence for the presence of these interactions, which is also supported by X-ray crystallographic and computational studies.

Synthesis method of tertiary amide compound

The invention provides a synthesis method of a tertiary amide compound, which comprises the following steps: reacting acyl chloride and N, N-disubstituted-4-oxopiperidinium salt used as raw materials,tris (2, 2 '-dipyridyl) ruthenium dichloride (II) used as a photosensitizer and triethylamine used as an alkali at room temperature for 3-12h under the protection of N2, and purifying to obtain the tertiary amide compound. The reaction is completed under the illumination condition, the cost is low, and the efficiency is high; the synthesis operation is simple and convenient, the reaction conditions are mild, and a method for synthesizing tertiary amide compounds without using harsh high-temperature heating conditions is developed; N, N-disubstituted-4-oxopiperidinium salt is adopted as a reaction raw material, is relatively stable in property and convenient to store, and is particularly suitable for industrial large-scale production.

APPLICATIONS of ORGANOLITHIUM and RELATED REAGENTS in SYNTHESIS. Part IV. A General Study of the Reaction of N,N-Dialkylpyridinecarboxamides with Lithium Diisopropylamide

The reactions of the N,N-dialkylpyridinecarboxamides (1), (2) and (3) derived from picolinic, nicotinic and isonicotinic acids with lithium diisopropylamides have been examied.It is shown that in contrast with N,N-diethylpyridinecarboxamides (1a), (2a) an