42205-87-8Relevant articles and documents
Evidence of an nN(amide) → π*ArInteraction in N-Alkyl- N, N′-diacylhydrazines
Deka, Jugal Kishore Rai,Sahariah, Biswajit,Sakpal, Sushil S.,Bar, Arun Kumar,Bagchi, Sayan,Sarma, Bani Kanta
supporting information, p. 7003 - 7007 (2021/05/26)
1,2-Dibenzoyl-1-tert-butylhydrazine (RH-5849) and related N-alkyl-N,N′-diacylhydrazines are environmentally benign insect growth regulators. Herein, we show that an unusual nN(amide) → π*Ar interaction mediated by a hydrazide amide nitrogen atom plays a crucial role in stabilizing their biologically active trans-cis (t-c) rotameric conformations. We provide NMR and IR spectroscopic evidence for the presence of these interactions, which is also supported by X-ray crystallographic and computational studies.
APPLICATIONS of ORGANOLITHIUM and RELATED REAGENTS in SYNTHESIS. Part IV. A General Study of the Reaction of N,N-Dialkylpyridinecarboxamides with Lithium Diisopropylamide
Epsztajn, Jan,Brzezinski, Jacek Z.,Jozwiak, Andrzej
, p. 401 - 441 (2007/10/02)
The reactions of the N,N-dialkylpyridinecarboxamides (1), (2) and (3) derived from picolinic, nicotinic and isonicotinic acids with lithium diisopropylamides have been examied.It is shown that in contrast with N,N-diethylpyridinecarboxamides (1a), (2a) an
