77924-05-1

Usage

Uses

Used in Analytical Chemistry:
N,N-Diisopropylisonicotinamide is used as a solvent in the extraction and separation of metal ions, facilitating the efficient and accurate analysis of metal ion concentrations in various samples.
Used in Pharmaceutical Industry:
1. As a pharmaceutical intermediate, N,N-Diisopropylisonicotinamide plays a crucial role in the synthesis of various drugs, contributing to the development of novel therapeutic agents.
2. As an additive in drug formulations, it improves the solubility and bioavailability of active pharmaceutical ingredients, enhancing the efficacy and safety of drug products.
Used in Gas Separation:
N,N-Diisopropylisonicotinamide is employed in the production of polymeric membranes for gas separation, enabling the efficient and selective separation of different gas species in various industrial processes.
Used in Material Synthesis:
N,N-Diisopropylisonicotinamide is utilized in the synthesis of novel materials with potential applications in catalysis and sensing, contributing to the development of advanced materials for various industrial and research purposes.

InChI:InChI=1/C12H18N2O/c1-9(2)14(10(3)4)12(15)11-5-7-13-8-6-11/h5-10H,1-4H3

Upstream product

• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 108-18-9 diisopropylamine 
• 15854-87-2 4-iodopyridine 
• 201230-82-2 carbon monoxide 
• 1570-45-2 isonicotinic acid ethylester 
• 4111-54-0 lithium diisopropyl amide 
• 14254-57-0 4-(chlorocarbonyl)pyridine 

Downstream Products

• 154865-57-3 4-Phenylpyrido<3,4-d>pyridazin-1(2H)-one 
• 868997-86-8 4-(diisopropylcarbamoyl)pyridin-3-ylboronic acid 
• 1443251-48-6 3-(4-fluorophenyl)-3-isobutylfuro[3,4-c]pyridin-1(3H)-one 
• 77924-11-9 3,3-diphenylfuro[3,4-c]pyridin-1(3H)-one 
• 42205-87-8 N-methyl-N-(2-oxo-2-phenylethyl)benzamide 
• 88329-47-9 N,N-Diisopropyl-3-benzoyl-4-pyridinecarboxamide 
• 104084-47-1 3-(Hydroxy-phenyl-methyl)-N,N-diisopropyl-isonicotinamide 
• 104084-54-0 3-(1-Hydroxy-cyclohexyl)-N,N-diisopropyl-isonicotinamide 
• 77924-06-2 3-[hydroxy(diphenyl)methyl]-N,N-bis(1-methylethyl)pyridine-4-carboxamide 

Relevant academic research and scientific papers

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead

This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study.

4-Pyridyl carbonyl compounds as thrips lures: Effectiveness for western flower thrips in Y-tube bioassays

In a search for chemical lures to manage the cosmopolitan crop pest western flower thrips (WFT), Frankliniella occidentalis, a Y-tube olfactometer was used to screen 20 compounds, including 18 4-pyridyl compounds. Comparison of Y-tube results for New Zealand flower thrips (NZFT), Thrips obscuratus, with field trapping data for ethyl nicotinate and ethyl isonicotinate, suggested that the minimum attractive dose (MAD) of an odor compound, where significantly (p -3 μL) and ethyl nicotinate (10-2 μL): methyl isonicotinate (10-6 μL), ethyl-2-chloropyridine-4-carboxylate (10-6 μL), ethyl isonicotinate (10-4 μL) and methyl 4-pyridyl ketone (10 -5 μL). The suitability of MAD for selecting compounds for further evaluation of practical lure efficacy is discussed. Comparisons of activities within homologous series of esters and ketones showed that attractant activity decreased with chain length. 4-Formyl pyridine was an attractant at a dose of 10-5 μL, but was repellent at higher doses (10-2- 10° μL).

INSECT BEHAVIOUR MODIFYING COMPOUNDS

The invention provides methods for controlling thrips populations using thrips-repelling and/or thrips-attracting agents. The agents are derivatives of pyridine. The invention also provides methods of preventing or minimising damage to plants by use of the same.

Catalytic Synthesis and Asymmetric Reduction of Pyridylglyoxylic Amides and Esters

The preparation of 2-pyridyl- and 4-pyridylglyoxylic esters and amides in moderate to high yields via palladium-catalyzed double carbonylation of 2-iodo- and 4-iodopyridines is reported. The effect of temperature, CO pressure, solvent, nature and concentr

APPLICATIONS of ORGANOLITHIUM and RELATED REAGENTS in SYNTHESIS. Part IV. A General Study of the Reaction of N,N-Dialkylpyridinecarboxamides with Lithium Diisopropylamide

The reactions of the N,N-dialkylpyridinecarboxamides (1), (2) and (3) derived from picolinic, nicotinic and isonicotinic acids with lithium diisopropylamides have been examied.It is shown that in contrast with N,N-diethylpyridinecarboxamides (1a), (2a) an