42247-74-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(2-hydroxyethyl)benzonitrile is utilized as a building block for the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products. Its unique chemical structure allows for the creation of various derivatives with potential therapeutic and pesticidal properties.
Used in Dye Production:
In the dye industry, 2-(2-hydroxyethyl)benzonitrile is employed as a key intermediate in the production of various dyes. Its chemical properties enable the synthesis of dyes with specific color characteristics and improved performance in different applications.
Used in Perfumery:
2-(2-hydroxyethyl)benzonitrile is used as a raw material in the perfume industry to create unique and complex fragrances. Its ability to form various chemical compounds allows for the development of novel scents and the enhancement of existing perfume formulations.
Used in Specialty Chemicals:
2-(2-hydroxyethyl)benzonitrile is also utilized in the production of specialty chemicals, which are tailored for specific applications in industries such as plastics, coatings, and textiles. Its versatility and reactivity make it a valuable component in the synthesis of these high-performance materials.

InChI:InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/m0/s1

Upstream product

• 5339-85-5 2-aminophenethyl alcohol 
• 143-33-9 sodium cyanide 
• 493-05-0 isochromane 
• 1074-16-4 2-bromophenylethyl alcohol 
• 151-50-8 potassium cyanide 

Downstream Products

• 4702-34-5 isochroman-1-one 
• 1597531-51-5 2-(2-((tert-butyldimethylsilyl)oxy)ethyl)benzonitrile 
• 1597518-36-9 ((S)-2-{3-[2-(2-hydroxyethyl)phenyl]-[1,2,4]oxadiazol-5-yl}pyrrolidin-1-yl)-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone 
• 1597531-24-2 (S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 
• 1597531-22-0 2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N-hydroxybenzamidine 
• 79536-84-8 (5-O-Tritylthymidin-3')(2-chlorphenyl)(2-cyano-4-nitrophenylaethyl)phosphorsaeureester 
• 79536-81-5 2-(2-Cyano-4-nitrophenyl)aethanol 
• 5398-76-5 Acetic acid 2-(2-cyano-phenyl)-ethyl ester 

Relevant academic research and scientific papers

A copper catalyzed novel method for synthesizing benzonitrile derivatives (by machine translation)

The invention relates to a copper catalyzed novel method for synthesizing benzonitrile derivatives. The method is to Benzylether or benzaldehyde compound as a substrate, the copper salt as catalyst condition, with the nitrogen source at certain temperature to prepare the benzonitrile derivatives. Synthesis of of the present invention compared with the previous method, only the one-step reaction steps, reaction time is relatively short, simple treatment after the mild reaction conditions. The present invention uses wider range of the substrate, including benzaldehyde class Benzylether and, in ethers as the substrate is used to synthesize a nitrile compounds has never been reported before, and the reaction time as the substrate benzaldehyde class without side reaction to occur, the separation of product to reach the highest yield 94%. (by machine translation)

CHEMICAL COMPOUNDS 428

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.

Nucleotide. XIV. Substituierte β-Phenylaethyl-Gruppen. Neue Schutzgruppen fuer Oligonucleotid-Synthesen nach dem Phosphorsaeuretriester-Verfahren

Various o- and p-substituted β-phenylethanols (2-10) have been synthesized and investigated as blocking groups in the phosphotriester approach.A large number of 5'-O-tritylated thymidine-3'-phosphotriesters (13-36) with two different phosphate protecting groups have been prepared, characterized, and studied according to their chemical stability and usefullness for oligonucleotide syntheses.The combination of a 5'-O-monomethoxytrityl- and a 3'-(2,5-dichlorophenyl, p-nitrophenylethyl)-phosphate function as in 18 turned out to possess optimal properties as a monomeric nucleotide building block due to the fact that these blocking groups can be quantitatively and selectively be removed without harming each other by trifluoroacetic acid in chloroform to 41, by oximate to 42, and by DBU to 43.The base-catalyzed removal of the monosubstituted phenylethyl groups by DBU or DBN respectively as well as the disubstituted phenylethyl groups by triethylamine in aprotic solvents is a β-elimination process leading to phosphodiesters without attack on the P-center.