4226-57-7

Usage

Uses

Used in Organic Chemistry:
2,2-diphenylbutyric acid is used as a chiral auxiliary for facilitating the asymmetric synthesis of various compounds, enhancing the selectivity and yield of desired enantiomers in chemical reactions.
Used in Pharmaceutical Production:
2,2-diphenylbutyric acid is used as a precursor in the synthesis of pharmaceuticals, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Production:
2,2-diphenylbutyric acid is also used as a precursor in the production of agrochemicals, aiding in the creation of more effective and targeted pesticides and other agricultural products.

InChI:InChI=1/C16H16O2/c1-2-16(15(17)18,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12H,2H2,1H3,(H,17,18)

Upstream product

• 544-16-1 n-Butyl nitrite 
• 5466-38-6 2,2-diphenyl-butyric acid amide 
• 5558-68-9 2,2-diphenyl-butyronitrile 
• 15719-64-9 methylammonium carbonate 
• 34885-21-7 1,1-diphenyl-1-ethyl-propan-2-one 
• 105539-07-9 2,2-diphenyl-butyraldehyde 
• 117-34-0 2,2-diphenylacetic acid 
• 75-03-6 ethyl iodide 
• 86-29-3 Diphenylacetonitrile 
• 74-96-4 ethyl bromide 
• 79328-68-0 methyl 2,2-diphenylbutyrate 
• 37896-66-5 1-Methoxy-1,1-diphenylpropan 
• 5180-33-6 1,1-Diphenyl-propan-1-ol 

Downstream Products

• 94911-65-6 2,2-diphenyl-butyric acid-(2-dimethylamino-ethyl ester); hydrochloride 
• 95292-65-2 2,2-diphenyl-butyric acid-(3-diethylamino-propyl ester); hydrochloride 
• 857198-56-2 2,2-diphenyl-butyryl chloride 
• 2618-37-3 2,2-diphenyl-butyric acid-(2-diethylamino-ethyl ester); hydrochloride 
• 762298-28-2 2,2-DIPHENYL-N-(3-{4-[3-(PROPIONYLAMINO)PHENYL]-1-PIPERIDINYL}PROPYL)BUTANAMIDE 
• 762299-40-1 N-[3-(1-{3-[(2,2-DIPHENYLBUTANOYL)AMINO]PROPYL}4-PIPERIDINYL)PHENYL]CYCLOPROPANECARBOXAMIDE 
• 1418028-18-8 C₁₆H₁₄O₂ 
• 38445-36-2 N-methyl-2-methyl-3-phenylindole 
• 1227083-53-5 N-methyl-1,1-diphenylpropan-1-amine 
• 23659-71-4 3-Ethyl-2,3-dihydro-2-methyl-3-phenyl-1H-isoindol-1-one 
• 113181-88-7 2,2-diphenyl-butyric acid-(3-dimethylamino-1-methyl-propyl ester) 
• 110050-22-1 2,2-diphenyl-butyric acid-(3-dimethylamino-propyl ester) 
• 905-00-0 2,2-diphenyl-butyric acid-(2-diethylamino-ethyl ester) 
• 564450-51-7 2-diazo-3-oxo-4,4-diphenyl-hexanoic acid methyl ester 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

Dirhodium(II) tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate]: An exceptionally effective Rh(II) catalyst for enantiotopically selective aromatic C-H insertions of diazo ketoesters

Dirhodium(II) tetrakis[N-tetrafluorophthaloyl-(S)-tert-leucinate], Rh2[(S)-TFPTTL]4, in which the phthalimido hydrogen atoms of the parent dirhodium(II) complex are substituted by fluorine atoms, dramatically enhances the reactivity and enantioselectivity (up to 97% ee) in intramolecular aromatic C-H insertion reactions of methyl 4-alkyl-2-diazo-4,4-diphenyl-3-oxopropionates. Catalysis with the use of 0.001 mol% of Rh2[(S)-TFPTTL]4 has achieved the highest turnover number (up to 98,000 with the methyl substituent) ever recorded for chiral dirhodium(II) complex-catalyzed carbene transformations, without compromising the yield or enantioselectivity of the process.

Molecular Modification of Anticholinergics as Probes for Muscarinic Receptors. Amino Esters of α-Substituted Phenylacetic Acid and Related Analogues

Two series of compounds having the general structure of C6H5CRR'COOCH2CH2NEt2 were synthesized and examined for their antispasmodic activities.These compounds were selected as structural probes for exploring the nature of muscarinic cholinergic receptor binding sites that interact with atropine-like anticholinergics.These studies indicate a rather strict size limitation for the hydrophobic region of the receptor and suggest intramolecular hydrogen bonding as a possible means to explain the observed stereoselectivity.