105539-07-9Relevant academic research and scientific papers
α-hydrdroxylic acid derivatives, their production and use
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Page column 18-19, (2010/11/30)
The present invention relates to carboxylic acid derivatives of the formula where the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs.
Reactions of a β-sultam ring with Lewis acids via the C-S bond cleavage
Iwama, Tetsuo,Ogawa, Miyoko,Kataoka, Tadashi,Muraoka, Osamu,Tanabe, Genzoh
, p. 8941 - 8974 (2007/10/03)
Selective C-S bond cleavage of a β-sultam ring was achieved by the reactions with Lewis acids. Aryl ketones or aldehyde were provided from 3- aryl-β-sultams whereas β-sultams bearing a poorly migratory substituent at C-3 gave trans-1,2,3-oxathiazolidine 2-oxides and/or cis-aziridines. These reactions were influenced by the cation-stabilizing capability of C-4 substituents and by the configuration of the substituents at C-3 and C-4. Some 4-alkenyl-3-aryl-β-sultams underwent tandem intramolecular cyclization to give bicyclo[3.2.1]- and [2.2.1]-γ-sultams via the processes of C-S bond cleavage, 1,2-aryl shift, cation-olefin cyclization and recombination of the sulfonyl anion.
