42265-67-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(TERT-BUTYL)-2-CHLOROANILINE is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs with improved efficacy and safety profiles. Its unique reactivity and selectivity make it a valuable building block in organic reactions for drug discovery and synthesis.
Used in Agrochemical Industry:
4-(TERT-BUTYL)-2-CHLOROANILINE is used as a precursor in the production of agrochemicals, such as crop protection agents. Its role in the synthesis of these agents helps in the development of effective and environmentally friendly solutions for agricultural applications.
Used in Chemical Industry:
4-(TERT-BUTYL)-2-CHLOROANILINE is used as a versatile intermediate in the synthesis of a wide range of commercial products in the chemical industry. Its stability and reactivity make it an essential component in the development of new materials and compounds with diverse applications.
Used in Organic Synthesis:
4-(TERT-BUTYL)-2-CHLOROANILINE is used as a building block in various organic reactions, providing unique reactivity and selectivity that facilitate the synthesis of complex organic compounds. Its presence in these reactions enhances the efficiency and yield of the desired products, making it a valuable asset in the field of organic chemistry.

InChI:InChI=1/C10H14ClN/c1-10(2,3)7-4-5-9(12)8(11)6-7/h4-6H,12H2,1-3H3

Upstream product

• 100141-30-8 acetic acid-(4-tert-butyl-2-chloro-anilide) 
• 103-84-4 Acetanilid 
• 507-20-0 tertiary butyl chloride 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 20330-45-4 4-tert-butylacetanilide 

Downstream Products

• 3972-55-2 1-tert-butyl-3-chloro-benzene 
• 71028-34-7 3-Chlor-4-fluor-tert.-butylbenzol 
• 180624-06-0 4-tert-butyl-2-chloro-6-iodoaniline 
• 100141-30-8 acetic acid-(4-tert-butyl-2-chloro-anilide) 
• 2359-09-3 5-t-butylisophthalic acid 
• 7498-54-6 3-t-Butylbenzoic acid 
• 155765-16-5 4-t-butyl-2-chloro-6-(methylthiomethyl)aniline 
• 1202512-74-0 C₁₃H₁₈ClN 
• 1263377-20-3 1-bromo-3-(tert-butyl)-5-chlorobenzene 
• 67740-14-1 C₁₁H₁₂ClN 
• 1338065-15-8 1-[(4-tert-butyl-2-pyrrolidin-1-yl-phenyl)methyl]-3-(2-oxo-1,3-dihydrobenzimidazol-4-yl)urea 
• 1338065-78-3 (4-tert-butyl-2-pyrrolidin-1-yl-phenyl)methanamine 
• 1338065-77-2 4-tert-butyl-2-pyrrolidin-1-yl-benzonitrile 

Relevant academic research and scientific papers

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

The invention relates to compounds of formula (I) wherein Ar, X, R1, R2, R3 and R4 are as defined herein and, pharmaceutical compositions thereof useful, either alone or in combination with other therapeutic agents as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV for the treatment or prophylaxis of HIV infection

Efficient reagents for the synthesis of 5-, 7-, and 5,7-substituted indoles starting from aromatic amines: Scope and limitations

Upon reaction with IPy2BF4, 4-substituted anilines give regioselectively the corresponding o-iodoanilines in nearly quantitative yield, in a process that can be carried out on a multigram scale. Palladium-catalyzed coupling of the resulting 2-iodoanilines with (trimethylsilyl)acetylene (TMSA), followed by efficient CuI-mediated nitrogen cyclization onto alkynes with concurrent elimination of the TMS substituent, allows a straightforward elaboration of 5-mono- and 5,7-disubstituted indoles from aromatic amines. This new approach to the aforementioned indoles does not requires protective groups on nitrogen at any step and can be adapted for preparing related 7-monosubstituted indoles. Moreover, examples iterating the process are given, allowing bis-annulation and sequential double annulation and resulting in synthesis of benzodipyrroles. Additionally, suitable conditions for iodination of some of the target indoles with IPy2BF4 are discussed.