42265-67-8

Basic information

• Product Name: 4-(TERT-BUTYL)-2-CHLOROANILINE
• Synonyms: 4-(TERT-BUTYL)-2-CHLOROANILINE;4-t-butyl-2-chloroaniline
• CAS NO: 42265-67-8
• Molecular Formula: C₁₀H₁₄ClN
• Molecular Weight: 183.68
• Mol File: 42265-67-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 84 °C
• Flash Point: 103.1°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.0265mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: 4-(TERT-BUTYL)-2-CHLOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYL)-2-CHLOROANILINE(42265-67-8)
• EPA Substance Registry System: 4-(TERT-BUTYL)-2-CHLOROANILINE(42265-67-8)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 42265-67-8(Hazardous Substances Data)

Usage

General Description

4-(tert-butyl)-2-chloroaniline is a chemical compound with the molecular formula C10H14ClN. It is an aromatic amine that is commonly used in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. The tert-butyl group attached to the nitrogen atom enhances the chemical's stability and reactivity, making it a valuable building block for many organic reactions. The chlorine substituent on the benzene ring also provides unique reactivity and selectivity in chemical transformations. Due to its versatile nature, 4-(tert-butyl)-2-chloroaniline is an important intermediate in the production of a wide range of commercial products. It is crucial for the development of new drugs, crop protection agents, and materials in the chemical industry. However, it is important to handle this chemical with care, as it may pose risks to human health and the environment if not managed properly.

InChI:InChI=1/C10H14ClN/c1-10(2,3)7-4-5-9(12)8(11)6-7/h4-6H,12H2,1-3H3

Upstream product

• 20330-45-4 4-tert-butylacetanilide 
• 103-84-4 Acetanilid 
• 507-20-0 tertiary butyl chloride 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 100141-30-8 acetic acid-(4-tert-butyl-2-chloro-anilide) 

Downstream Products

• 945012-60-2 C₁₂H₁₈NCl 
• 180624-17-3 4-tert-butyl-6-chloro-2-[2-(trimethylsilyl)ethynyl]aniline 
• 769961-21-9 4-tert-butyl-2-chloro-1-isothiocyanato-benzene 
• 71028-34-7 3-Chlor-4-fluor-tert.-butylbenzol 
• 1263377-20-3 1-bromo-3-(tert-butyl)-5-chlorobenzene 

Relevant articles and documents

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

Efficient reagents for the synthesis of 5-, 7-, and 5,7-substituted indoles starting from aromatic amines: Scope and limitations

Upon reaction with IPy2BF4, 4-substituted anilines give regioselectively the corresponding o-iodoanilines in nearly quantitative yield, in a process that can be carried out on a multigram scale. Palladium-catalyzed coupling of the resulting 2-iodoanilines with (trimethylsilyl)acetylene (TMSA), followed by efficient CuI-mediated nitrogen cyclization onto alkynes with concurrent elimination of the TMS substituent, allows a straightforward elaboration of 5-mono- and 5,7-disubstituted indoles from aromatic amines. This new approach to the aforementioned indoles does not requires protective groups on nitrogen at any step and can be adapted for preparing related 7-monosubstituted indoles. Moreover, examples iterating the process are given, allowing bis-annulation and sequential double annulation and resulting in synthesis of benzodipyrroles. Additionally, suitable conditions for iodination of some of the target indoles with IPy2BF4 are discussed.