945012-60-2Relevant academic research and scientific papers
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
O'Meara, Jeff A.,Jakalian, Araz,LaPlante, Steven,Bonneau, Pierre R.,Coulombe, Rene,Faucher, Anne-Marie,Guse, Ingrid,Landry, Serge,Racine, Jennifer,Simoneau, Bruno,Thavonekham, Bounkham,Yoakim, Christiane
, p. 3362 - 3366 (2007)
High-throughput screening hit 1 was identified as a potent, broad-spectrum, non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 replication. Analysis of the bound conformation of analogs of this inhibitor via molecular modeling and NMR contrib
