42285-85-8

Basic information

• Product Name: 8-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
• CAS NO: 42285-85-8
• Molecular Formula: C₁₄H₁₃N₅O₂
• Molecular Weight: 283.2853
• Mol File: 42285-85-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 513.1°C at 760 mmHg
• Flash Point: 264.1°C
• Density: 1.324g/cm³
• Vapor Pressure: 1.22E-10mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 8-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione(42285-85-8)
• EPA Substance Registry System: 8-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione(42285-85-8)

Safety Data

• Hazardous Substances Data: 42285-85-8(Hazardous Substances Data)

Usage

General Description

8-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione is a chemical compound with a complex and specific structure. It contains a pyrimido[5,4-e][1,2,4]triazine core with an ethyl group at the 8th position, a methyl group at the 6th position, and a phenyl group at the 3rd position. The compound also contains a dione functional group at the 5th and 7th positions, which gives it a cyclic and stable structure. This chemical compound is important for its potential applications in medicinal chemistry, pharmaceuticals, and material science, as the unique structure and functional groups present in it can be utilized for various purposes in these fields.

Upstream product

• 42285-76-7 6-Methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione 
• 75-03-6 ethyl iodide 
• 64-67-5 diethyl sulfate 

Relevant articles and documents

General syntheses of 1-alkyltoxoflavin and 8-alkylfervenulin derivatives of biological significance by the regioselective alkylation of reumycin derivatives and the rates of transalkylation from 1-alkyltoxoflavins into nucleophiles

Regioselective alkylations of reumycin derivatives under alkaline conditions with a dialkyl sulfate or alkyl halide in 1,4-dioxane or DMF to provide 1-alkyltoxoflavin or 8-alkylfervenulin derivatives of biological significance, are described. Namely, the primary and secondary alkylations of reumycin derivatives with appropriate dialkyl sulfates or alkyl bromides under alkaline conditions in 1,4-dioxane gave predominantly 1-alkyltoxoflavin derivatives, while the same alkylations in DMF instead of 1,4-dioxane gave predominantly 8-alkylfervenulin derivatives. In the case of tertiary alkylation, the reumycin derivative with 2-bromo-2-methylpropane in both solvents under the same conditions yielded only the 1-alkyltoxoflavin derivative. Moreover, the rates of transalkylation from 1-alkyltoxoflavin derivatives into nucleophiles, e.g. DMF and n-butylamine, are also described. That is, the toxoflavin derivatives possessing a primary alkyl group at the 1-position were easily dealkylated from the 1-position by heating with DMF, whereupon reumycin (i.e., 1-dealkyltoxoflavin, 8-dealkylfervenulin) derivatives were formed. In other words, transalkylation from the toxoflavin derivatives into DMF took place, However, the transalkylation of 1-alkyltoxoflavin derivatives possessing a secondary or tertiary alkyl group at the 1-position was not observed under such conditions. On the other hand, when heating 1-alkyltoxoflavin derivatives with n-butylamine in 1,4-dioxane, the transalkylations were more easily observed even in the case of 1-alkyltoxoflavin derivatives substituted by a tertiary alkyl group.