42288-54-0

Usage

Uses

Used in Organic Synthesis:
(3,5-ditert-butylphenyl)acetic acid is used as a reagent in organic synthesis for its ability to participate in a wide range of chemical reactions, facilitating the creation of diverse organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (3,5-ditert-butylphenyl)acetic acid is utilized as an intermediate. Its role is crucial in the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Agrochemicals:
(3,5-ditert-butylphenyl)acetic acid also serves as an intermediate in the production of agrochemicals, playing a part in creating substances that help improve crop yields and protect plants from pests and diseases.
Used as a Chiral Auxiliary:
In asymmetric synthesis, (3,5-ditert-butylphenyl)acetic acid is employed as a chiral auxiliary. It aids in the synthesis of enantiomerically pure compounds, which is essential for the production of many pharmaceuticals and agrochemicals where stereochemistry is critical for biological activity.
Used as a Ligand in Catalysis:
(3,5-ditert-butylphenyl)acetic acid functions as a ligand in catalytic processes, enhancing the efficiency and selectivity of various chemical reactions, which is particularly important in the synthesis of complex organic molecules.
Used in Material Science:
With potential applications in the development of new materials, (3,5-ditert-butylphenyl)acetic acid contributes to the advancement of material science, possibly leading to the creation of innovative materials with unique properties.
Used in Pharmaceutical Screening:
(3,5-ditert-butylphenyl)acetic acid is also used in pharmaceutical screening processes, where it may help identify new drug candidates or optimize existing ones through its interactions with biological targets.
Safety Note:
It is important to handle (3,5-ditert-butylphenyl)acetic acid with care due to its potential to cause skin and eye irritation. Appropriate safety measures should be taken during its use in laboratories and industrial settings.

Upstream product

• 36720-94-2 1,3-di-tert-butyl-5-ethynylbenzene 
• 62938-08-3 3,5-di-tert-butylbenzyl bromide 
• 77387-58-7 2-[3,5-di-(tert-butyl)phenyl]acetonitrile 
• 15181-11-0 3, 5-di-tert-butyltoluene 

Downstream Products

• 79726-40-2 2-(3,5-Di-tert-butylphenyl)essigsaeure-methylester 
• 1248682-78-1 ((1R,3S)-5-iodo-6,8-dimethoxy-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 2-(3,5-di-tert-butylphenyl)acetate 
• 79726-42-4 2-(3,5-Di-tert-butylphenyl)-2-phenoxyessigsaeure-methylester 
• 79726-43-5 2-(3,5-Di-tert-butylphenyl)-2-phenoxyacetamid 
• 79726-39-9 2-(3,5-Di-tert-butylphenyl)-2-phenoxy-acetonitril 
• 79726-41-3 2-Brom-2-(3,5-di-tert-butylphenyl)essigsaeure-methylester 
• 858859-72-0 1-butyl-3-[5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-7-(4-methoxy-benzylamino)-[1,8]naphthyridin-2-yl]-urea 
• 858859-73-1 1-(7-amino-5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-yl)-3-butyl-urea 
• 858859-71-9 4-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-N²-(4-methoxy-benzyl)-[1,8]naphthyridine-2,7-diamine 
• 858859-76-4 5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-ylamine 
• 858859-68-4 toluene-4-sulfonic acid 2-(3,5-di-tert-butyl-phenyl)-ethyl ester 
• 858859-67-3 2-(3,5-di-tert-butylphenyl)ethanol 

Relevant academic research and scientific papers

Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.

CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA]

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1'), (100), (100'), (200) and (200') and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.

Synthesis of a soluble ureido-naphthyridine oligomer that self-associates via eight contiguous hydrogen bonds

(Chemical Equation Presented) An iterative synthetic route to organic-soluble ureido-naphthyridine oligomers has been developed. Use of this protocol allowed synthesis of a short ureido-naphthyridine oligomer, which presents a self-complementary DDAADDAA hydrogen bonding array (D = hydrogen bond donor, A = hydrogen bond acceptor). Strong self-association via eight hydrogen bonds was observed in organic solution.

Preparation of Diaryl and Aryl tert-Butyl α-Thioxoketones

The preparation of the α-haloketones 6, 13-16, 19, and 20 is reported. 13 or its precursor, the acyloin 9, respectively, is conveniently obtained by a Seebach synthesis. - Reaction of the haloketones with tetraethylammonium thiosulfate (21) yields the Bunte salts 22-27 wich form the thioketones 28-33 on cleavage with aqueous alkali. 29 is stable as a crystalline, blue monomer in contrast with other aromatic α-thioxoketones.This ist also true for the aromatic-aliphatic derivatives 30 and 31 as well as their isomers 32 and 33 wich do not dimerize.

ESR Spectroscopic Studies of Donor-Acceptor-Substituted Carbon Radicals

The radicals 2, 3a, 4, and 12 as well as 3b, and 17 were generated for ESR spectroscopic studies either by hydrogen abstraction with aminyl radicals or by oxidation with lead dioxide.Hydrogen abstraction from 5 did not give 6 but a secondary radical 7.Radical 16 was formed by reduction of the corresponding pyridinium iodide by zinc, whereas reduction of 13, and 8 afforded the radicals 15, and 11, respectively.The analysis of the ESR spectra allowed the determination of the spin density at various positions of these radicals.Furthermore, theoretical calculations of spin density - performed also for the radicals 1a and b, 21 and 22 - revealed the spin density distribution within the amino(cyano)alkyl group and the effects of further substituents on this.