858859-67-3

Usage

Type of compound

Organic

Family

Alcohols

Derivation

Substitution of hydrogen atom in the benzene ring with tert-butyl groups at the 3 and 5 positions

Industrial and consumer product applications

Fragrances, cosmetics, and pharmaceuticals

Use in manufacturing

Stabilizer and antioxidant in polymers, plastics, and rubber products

Antioxidant properties

Beneficial in skincare product production and food and beverage packaging stabilization

Upstream product

• 42288-54-0 2-(3,5-Di-tert-butylphenyl)essigsaeure 
• 77387-58-7 2-[3,5-di-(tert-butyl)phenyl]acetonitrile 
• 99758-86-8 2-[3,5-di(tert-butyl)phenyl]acetaldehyde 
• 15181-11-0 3, 5-di-tert-butyltoluene 
• 62938-08-3 3,5-di-tert-butylbenzyl bromide 

Downstream Products

• 858859-72-0 1-butyl-3-[5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-7-(4-methoxy-benzylamino)-[1,8]naphthyridin-2-yl]-urea 
• 858859-73-1 1-(7-amino-5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-yl)-3-butyl-urea 
• 858859-71-9 4-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-N²-(4-methoxy-benzyl)-[1,8]naphthyridine-2,7-diamine 
• 858859-76-4 5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-ylamine 

Relevant academic research and scientific papers

Synthesis of a soluble ureido-naphthyridine oligomer that self-associates via eight contiguous hydrogen bonds

(Chemical Equation Presented) An iterative synthetic route to organic-soluble ureido-naphthyridine oligomers has been developed. Use of this protocol allowed synthesis of a short ureido-naphthyridine oligomer, which presents a self-complementary DDAADDAA hydrogen bonding array (D = hydrogen bond donor, A = hydrogen bond acceptor). Strong self-association via eight hydrogen bonds was observed in organic solution.

DERIVATIVES OF AROMATIC CYCLIC ALKYLETHERS

The present invention provides compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein: R1 and R2 are each alkyl; n is an integer of from 1 to 4; x is oxygen or -(CH2)m-; m is an integer of from 1 to 3; y is oxygen or sulfur; and p is an integer of from 1 to 4. These compounds are inhibitors of COX-I and/or COX-II, and are useful for the treatment of inflammation-associated disorders. The present invention also provides pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for treating inflammation-associated disorders in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal