4230-26-6

Usage

Use

Chemotherapy drug used to treat certain types of leukemia

Family

Purine nucleoside analogues

Mechanism of action

Inhibits the synthesis of DNA and RNA in cancer cells

Prodrug

Must undergo conversion in the body to its active form

Administration

Intravenously

Approved for

Treatment of acute lymphoblastic leukemia in pediatric patients

Off-label use

Other leukemias and lymphomas

Common side effects

Nausea, vomiting, diarrhea, bone marrow suppression (increased risk of infection and bleeding)

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 87-42-3 6-chloropurine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 1393886-21-9 C₁₈H₁₄N₆O₂ 
• 1393886-07-1 3-(4-nitrobenzyl)-3H-benzo[4,5]imidazo[2,1-i]purine 
• 112089-10-8 9-(4-Aminobenzyl)-6-(dimethylamino)-9H-purine 
• 13233-83-5 methyl-[9-(4-nitro-benzyl)-9H-purin-6-yl]-amine 
• 13233-85-7 dimethyl-[9-(4-nitro-benzyl)-9H-purin-6-yl]-amine 

Relevant academic research and scientific papers

4,7-disubstituted 7h-pyrrolo[2,3-d]pyrimidines and their analogs as antiviral agents against zika virus

Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative core structure. Overall, we have identified 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs including compounds 1, 8 and 11 as promising antiviral agents against flaviviruses ZIKV and dengue virus (DENV). While the molecular target of these compounds is yet to be elucidated, 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs are new chemotypes in the design of small molecules against flaviviruses, an important group of human pathogens.

Synthesis, biological activity, and SAR of antimycobacterial 9-aryl-, 9-arylsulfonyl-, and 9-benzyl-6-(2-furyl)purines

9-Aryl-, 9-arylsulfonyl- and 9-benzyl-6-(2-furyl)purines were synthesized by N-alkylation or N-arylation of the purine followed by Stille coupling to introduce the furyl substituent in the 6-position and the compounds screened for activity against Mycobac

Purine N-alkylated derivatives. SRN1 synthesis and functional group transformations

Purine and its 6-chloro, 6-methoxy, 6-amino and 2-amino-6-chloro derivatives are efficient nucleophiyles in SRN1 reactions with various functionalized gem halo-nitroalkanes as substrates in which good regioselectivity on N9 is observ