423183-10-2

Basic information

• Product Name: C₂₆H₂₁ClN₆O
• CAS NO: 423183-10-2
• Molecular Weight: 468.945
• Mol File: 423183-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₁ClN₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₁ClN₆O(423183-10-2)
• EPA Substance Registry System: C₂₆H₂₁ClN₆O(423183-10-2)

Safety Data

• Hazardous Substances Data: 423183-10-2(Hazardous Substances Data)

Upstream product

• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 98305-75-0 2-amino-6-(4-chlorophenyl)pyrimidin-4-ol 
• 423184-77-4 2-(3-methoxyphenyl)quinoline-4,6-diamine 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 27834-99-7 ethyl (3-methoxybenzoyl)acetate 

Relevant articles and documents

Quinolinyl pyrimidines: Potent inhibitors of NDH-2 as a novel class of anti-TB agents

NDH-2 is an essential respiratory enzyme in Mycobacterium tuberculosis (Mtb), which plays an important role in the physiology of Mtb. Herein, we present a target-based effort to identify a new structural class of inhibitors for NDH-2. High-throughput screening of the AstraZeneca corporate collection resulted in the identification of quinolinyl pyrimidines as the most promising class of NDH-2 inhibitors. Structure-activity relationship studies showed improved enzyme inhibition (IC50) against the NDH-2 target, which in turn translated into cellular activity against Mtb. Thus, the compounds in this class show a good correlation between enzyme inhibition and cellular potency. Furthermore, early ADME profiling of the best compounds showed promising results and highlighted the quinolinyl pyrimidine class as a potential lead for further development.