42345-29-9

Basic information

• Product Name: 2-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-chromene-8-carbaldehyde
• Synonyms: 2-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-chromene-8-carbaldehyde
• CAS NO: 42345-29-9
• Molecular Weight: 300.698
• Mol File: 42345-29-9.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-chromene-8-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-chromene-8-carbaldehyde(42345-29-9)
• EPA Substance Registry System: 2-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-chromene-8-carbaldehyde(42345-29-9)

Safety Data

• Hazardous Substances Data: 42345-29-9(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 122-01-0 4-chloro-benzoyl chloride 
• 100-97-0 hexamethylenetetramine 
• 22609-52-5 4'-Chloro-7-hydroxyflavone 

Downstream Products

• 1372630-59-5 9-benzoyl-2-(4-chlorophenyl)pyrano[2,3-f]chromene-4,8-dione 
• 1372630-63-1 2-(4-chlorophenyl)-9-(4-methylbenzoyl)pyrano[2,3-f]chromene-4,8-dione 

Relevant articles and documents

Synthesis and antiproliferative activity of some dihydro-1 H-furo[2,3-c]pyrazole-Flavone hybrids

A new series of dihydro-1 H-furo[2,3-c]pyrazole-flavone hybrids were synthesized from one-pot four-component reaction of β-keto ester (1), hydrazine (2),7-hydroxy 8-formyl flavones (3), pyridiniumylide (4) in presence of NEt3 as catalyst under ethanol reflux conditions and their antiproliferative properties were evaluated against human cancer cell lines, namely, laryngeal carcinoma (Hep2), lung adenocarcinoma (A549) and cervical cancer (HeLa). The best among them, furo[2,3-c]pyrazole-flavone with C4′-methoxy substitution was selected for further structure activity relationship (SAR) studies. Among the derivatives, (4S,5S)-ethyl 4-(7-hydroxy-5-methoxy-4-oxo-2-(2,4,6-trimethoxyphenyl)-4H-chromen-8-yl)-3-methyl-4,5-dihydro-1 H-furo[2,3-c]pyrazole-5-carboxylate (8r) showed most potent cytotoxic activity against all three cancer cell lines. Toxicity studies revealed that the dihydro-1H-furo[2,3-c]pyrazole-flavones are specifically target the cancer cell lines.

Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation

A series of novel flavonoid analogues were designed and synthesized. The aimed compounds for urease inhibitory activities were clearly superior to the control drug thiourea (more than 10 times). Among these compounds, L2 (IC50 = 1.343 μM) and L12 (IC50 = 1.207 μM) exhibited the most excellent urease inhibitory activity in vitro. The molecular dockings of L2, L12 and L22 into urease were performed to explore the binding modes and their structure-activity relationship. Furthermore, these aimed compounds showed good druggable properties.

Synthesis of 3-aroylcoumarin-flavone hybrids

A facile two step synthesis of 3-aroylcoumarin-flavone hybrids was achieved from 7-hydroxyflavone and α- oxoketene dithioacetals. In the first step 7-hydroxyflavone was regioselectively formylated under Duff reaction conditions. Resulting 8-formyl-7-hydro