4237-37-0

Basic information

• Product Name: 2-tert-Butyl-6-chlorophenol
• Synonyms: 2-tert-Butyl-6-chlorophenol;NSC 203031
• CAS NO: 4237-37-0
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.6626
• Mol File: 4237-37-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 221℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.109
• Vapor Pressure: 0.074mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 2-tert-Butyl-6-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butyl-6-chlorophenol(4237-37-0)
• EPA Substance Registry System: 2-tert-Butyl-6-chlorophenol(4237-37-0)

Safety Data

• Hazardous Substances Data: 4237-37-0(Hazardous Substances Data)

Usage

General Description

2-tert-Butyl-6-chlorophenol is a chemical compound that belongs to the class of phenols. It has a molecular formula C10H14ClOH and a molecular weight of 184.67 g/mol. This chemical is a derivative of phenol, containing a tert-butyl group and a chlorine atom. It is commonly used as an antimicrobial agent in personal care products, such as soaps, lotions, and deodorants, due to its ability to inhibit the growth of bacteria and fungi. It is also utilized as a preservative in industrial processes and products. However, prolonged exposure to 2-tert-Butyl-6-chlorophenol can lead to skin irritation and allergic reactions in some individuals, and it may have environmental impacts due to its persistence in water and soil.

InChI:InChI=1/C10H13ClO/c1-10(2,3)7-5-4-6-8(11)9(7)12/h4-6,12H,1-3H3

Upstream product

• 95-57-8 2-monochlorophenol 
• 115-11-7 isobutene 
• 60803-25-0 2-(tert-butyl)-4-iodophenol 
• 60803-27-2 2-bromo-6-tert-butyl-4-iodophenol 
• 88-18-6 2-tert-Butylphenol 
• 60803-28-3 2-Chlor-4-iod-6-tert-butylphenol 

Downstream Products

• 13395-86-3 2-(tert-butyl)-4,6-dichlorophenol 
• 60935-50-4 4-bromo-2-(tert-butyl)-6-chlorophenol 

Relevant articles and documents

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Toward a Catalytic Atroposelective Synthesis of Diaryl Ethers Through C(sp 2)-H Alkylation with Nitroalkanes

We report studies toward a small-molecule-catalytic approach to access atropisomeric diaryl ethers that proceeds through a C(sp 2)-H alkylation using nitroalkanes as the alkyl source. A quaternary ammonium salt derived from quinine, containing

2,2,6,6-Tetramethylpiperidine-catalyzed, ortho-selective chlorination of phenols by sulfuryl chloride

2,2,6,6-Tetramethylpiperidine (TMP)-catalyzed (1- 10%) chlorinations of phenols by SO2Cl2 in aromatic solvents are more ortho selective than with primary and less hindered secondary amine catalysts. Ortho-selective chlorination is successful even with electron deficient phenols such as 2-hydroxybenzaldehyde and 2'- hydroxyacetophenone. Notably, ortho selectivity increases with the reaction temperature. On the other hand, tetraalkylammonium chloride-catalyzed chlorinations are moderately para selective.