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Usage

Uses

Used in Pharmaceutical Industry:
N~2~-formylglycinamide is used as a therapeutic agent for the treatment of cancer and other diseases related to purine metabolism. Its potential therapeutic applications are being studied due to its role in the biosynthesis of purine nucleotides, which are essential for various cellular processes and have been implicated in the development and progression of certain diseases.
Used in Research Applications:
N~2~-formylglycinamide is used as a research tool for studying the mechanisms of purine nucleotide biosynthesis and its role in various diseases. It can be used to investigate the regulation of purine metabolism and the development of novel therapeutic strategies targeting this pathway.

Upstream product

• 64-18-6 formic acid 
• 598-41-4 H-Gly-NH₂ 
• 141-53-7 sodium formate 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 128038-38-0 C₆H₉NO₄ 

Downstream Products

• 1238784-62-7 4'-[[2-n-Propyl-4-methyl-6-(1-aminocarbonylmethyl-4-isobutyl-5-methyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate 

Relevant academic research and scientific papers

Neighbouring Group Participation of the N-Acyl Function. I: A Selective Conversion of Nitriles into Carboxamides by Formic Acid

Aliphatic α-(acylamino)nitriles react with formic acid at room temperature to give the corresponding α-(acyl-amino)carboxamides with concomitant formation of one mole of carbon monoxide. This new reaction, which was first observed with 2-acylamino-2-cyano-3,6-dihydro-2H-thiapyranes 1, can also be used to convert other N-(α-cyanoalkyl) amides such as N-cyanomethylbenzamides 3, 5 and the 3,4-dihydro Reissert compound 16 into the corresponding carboxamides. Another application is a synthesis of 2-formylaminoacetamides 11. A mechanism for the reaction is proposed.

A Convenient Synthesis of Primary Amines Using Sodium Diformylamide as A Modified Gabriel Reagent

Sodium diformylamide (1) was used as a convenient substitute for phthalimide in the Gabriel synthesis of primary amines.Reagent 1 undergoes smooth N-alkylation with alkyl halides or p-toluenesulfonates 2 in acetonitrile or dimethylformamide to give the corresponding N,N-diformylalkylamines 3 in good yields, except with alkylating agents which are susceptible to base-catalyzed elimination.The formyl group of 3 can be easily removed by hydrochloric acid to give the corresponding alkylamine hydrochlorides 5 or free alkylamines 4.