4239-25-2

Usage

Uses

Used in Organic Synthesis:
2,2-dimethylbutane-1,4-diyl dimethanesulfonate is used as a reagent in organic synthesis for introducing the dimethanesulfonate group onto a molecule. This allows for the modification of the molecule's properties and reactivity, facilitating various chemical reactions and transformations.
Used as a Protecting Group for Alcohols:
In the field of organic chemistry, 2,2-dimethylbutane-1,4-diyl dimethanesulfonate is used as a protecting group for alcohols during organic reactions. This protects the alcohol functionality from unwanted side reactions, allowing for selective reactions to occur at other sites on the molecule. The protecting group can be easily removed after the desired reaction has taken place, regenerating the original alcohol.
Used in Pharmaceutical Industry:
2,2-dimethylbutane-1,4-diyl dimethanesulfonate is used in the pharmaceutical industry for the synthesis of various drug molecules. Its ability to introduce the dimethanesulfonate group and protect alcohol functionalities makes it a valuable tool in the development of new pharmaceutical compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2,2-dimethylbutane-1,4-diyl dimethanesulfonate is utilized for the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in organic synthesis allows for the creation of new compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Material Science:
2,2-dimethylbutane-1,4-diyl dimethanesulfonate is employed in material science for the synthesis of various materials with specific properties. Its ability to modify the properties of molecules can lead to the development of new materials with enhanced performance in areas such as polymers, coatings, and adhesives.

Upstream product

• 32812-23-0 2,2-dimethylbutane-1,4-diol 
• 75-75-2 methanesulfonic acid 
• 597-43-3 2,2-dimethylsuccinic acid 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

A Spiroalkylation Method for the Stereoselective Construction of α-Quaternary Carbons and Its Application to the Total Synthesis of (R)-Puraquinonic Acid

Cyclic α-quaternary carbon stereocenters were prepared from biselectrophillic substrates and an easily prepared chiral bicyclic sulfonyl lactam. This was achieved in two steps by spiroalkylation, employing biphasic reaction conditions with a phase-transfer catalyst, followed by reduction and alkylation with a series of alkyl halide electrophiles. The products of this method were isolated in good yields with with high levels of diastereoselectivity. This methodology was employed in the enantioselective total synthesis of (R)-puraquinonic acid (1) for a late-stage installation of the α-quaternary carbon stereocenter. This enabled the shortest synthesis of 1 to date, an eight-pot sequence providing an overall yield of 14%.

NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY

The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma receptors using them. Also provided are methods of using aryl sulfones and related compounds as modulators of ROR-gamma to treat ROR-gamma mediated diseases

The regiochemistry of cyclization of α-sulfenyl-, α-sulfinyl-, and α-sulfonyl-5-hexenyl radicals: Procedures leading to regioselective syntheses of cyclic sulfones and sulfoxides

A study of the cyclization of α-sulfenyl-, α-sulfinyl-, and α-sulfonyl-5-hexenyl and 5-methyl-5-hexenyl radicals reveals a unique contrast in the mode of ring closure of the radicals. In the case of the 5-hexenyl radicals, the sulfinyl-substituted species displays unexpected regioselectivity relative to its analogues. Thus, while the α-S- and α-SO2-5-hexenyl radicals give measurable and increasing quantities of 6-endo product, the α-sulfinyl species cyclizes with high selectivity (95.5:4.5) via a 5-exo mode. By contrast, ring closure of the 5-methyl-5-hexenyl radicals is found to give substantially the 6-endo product in all cases. It is the α-sulfonyl-5-methyl-5-hexenyl radical that now exhibits high regioselectivity (97.5:2.5) for 6-endo closure: an illustration of the synthetic value of this observation is the independent synthesis of the model cyclohexyl sulfone 61 in high yield. It is found that ring closure under the conditions employed occurs irreversibly in all cases.