42408-51-5

Upstream product

• 707-61-9 3-Methyl-1-phenyl-2-phospholene 1-oxide 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 78-79-5 isoprene 

Downstream Products

• 125344-79-8 2-Iodo-3-methyl-1-oxo-1-phenyl-1λ⁵-phospholan-3-ol 
• 125344-81-2 Acetic acid 3-hydroxy-3-methyl-1-oxo-1-phenyl-1λ⁵-phospholan-2-yl ester 
• 125344-82-3 3-Methyl-1-oxo-1-phenyl-2-thiocyanato-1λ⁵-phospholan-3-ol 
• 125344-80-1 3-Methyl-2-methylthio-1-phenyl-2-phospholene 1-oxide 
• 42408-53-7 2,3-Epoxy-3-methyl-1-phenylphospholane 1-oxide 

Relevant academic research and scientific papers

Research on phospha sugar analogues to develop novel multiple type molecular targeted antitumor drugs against various types of tumor cells

The synthesis and antitumor activity evaluation of new branched phospha sugars, especially deoxybromophospha sugar derivatives or bromophospholanes of 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide (DBMPP: 3) and 2,3,4-tribromo-3-methyl-1- phenylphospho

Phospho Sugars; Novel Preparation and Their Glycosyl Compounds

Treatment of 1-phenyl-2-, and -3-phospholene 1-oxides with N-bromosuccinimide affords 4-bromo-1-phenyl-2-phospholene 1-oxide.Substitution of the bromide with acetate, followed by stereoselective oxidation with osmium tetroxide and peracetylation with acetic anhydride/pyridine affords phospho sugar derivatives of tetrafuranose.Furthermore, N-, O-, and S-glycosyl compounds of phospho sugars can be prepared from 3-methyl-1-phenyl-2-phospholene 1-oxide by bromination and nucleophilic substitution reactions.This is a novel and excellent route to prepare phospho sugar derivatives.