42415-65-6Relevant academic research and scientific papers
2-(4-CHLOROPHENOXY)-N-((1 -(2-(4-CHLOROPHENOXY)ETHYNAZETIDIN-3-YL)METHYL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES
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Page/Page column 75-76, (2019/01/21)
The invention is directed to substituted azetidine derivatives. Specifically, the invention is directed to compounds according Formula I: (I) wherein C, D, L1,L2,L3,R1, R2, R4, R5, R6, z2, z4, z5, and z6are as defined herein; and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are 2-(4-chlorophenoxy)-N-((l- (2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds.
Gold(i) "click" 1,2,3-triazolylidenes: Synthesis, self-assembly and catalysis
Kilpin, Kelly J.,Paul, Ursula S. D.,Lee, Ai-Lan,Crowley, James D.
supporting information; experimental part, p. 328 - 330 (2011/03/17)
Novel gold(i) "click" carbene(1,2,3-triazolylidene) complexes have been synthesised, characterised and exploited for the self-assembly of a metallomacrocycle and as precatalysts for gold(i)-catalysed reactions.
Catalytic transformations of diazo compounds promoted by platinum(0) and dicationic platinum(II) complexes
Bertani, Roberta,Biasiolo, Monica,Darini, Katia,Michelin, Rino A,Mozzon, Mirto,Visentin, Fabiano,Zanotto, Livio
, p. 32 - 39 (2007/10/03)
9-Diazofluorene (DAF) is decomposed either stoichiometrically or catalytically in the presence of the platinum(0) complex [Pt(C2H4)(PPh3)2] to give difluoren-9-ylidene-hydrazine in high yield. Under analogous reaction conditions, diphenyldiazomethane gives mostly the azine, Ph2CNNCPh2, while ethyl diazoacetate (EDA) affords, in low yield, a mixture of diethyl fumarate and maleate in approximately 10:1 molar ratio. The cyclopropanation of styrene with EDA is catalyzed by a series of dicationic complexes of the type [PtL2(NCCH3)2][Y]2 (L2=2PPh3, Ph2PCH=CHPPh2, Ph2PCH2CH2PPh2; Y=BF4, CF3SO3) in 1,2-dichloroethane at 60 °C for 24 h. DAF and EDA undergo insertion reactions into the OH bond of alcohols ROH (R=Me, Et, t-Bu, CH2CHCH2, Ph) at 25 °C in CH2Cl2-ROH (DAF or EDA-ROH molar ratio 1/20) in the presence of 1% mol of several dicationic platinum(II) complexes to give the corresponding ethers in excellent yields.
Ruthenium complexes containing diamine-based ligands as catalysts for insertion of carbenes into O-H bonds of alcohols
Simal, Francois,Demonceau, Albert,Noels, Alfred F.
, p. 63 - 66 (2007/10/03)
Ruthenium complexes with N-(p-toluenesulfonyl)-diamine ligands are efficient catalysts for insertion of carbenes generated from diazo compounds into O-H bonds of alcohols.
Insertion of carbenes into O-H bonds of alcohols catalysed by platinum complexes
Schils, Raphael,Simal, Francois,Demonceau, Albert,Noels, Alfred F.,Eremenko, Igor L.,Sidorov, Aleksei A.,Nefedov, Sergei E.
, p. 7849 - 7852 (2007/10/03)
The addition of diazoesters to alcohols in the presence of a catalytic amount of platinum complexes provides the corresponding O-H insertion products in good to excellent yields.
TRANSITION-METAL-CATALYZED REACTIONS OF DIAZOCOMPOUNDS, EFFICIENT SYNTHESIS OF FUNCTIONALIZED ETHERS BY CARBENE INSERTION INTO THE HYDROXYLIC BOND OF ALCOHOLS
Noels, A. F.,Demonceau, A.,Petiniot, N.,Hubert, A. J.,Teyssie, Ph.
, p. 2733 - 2739 (2007/10/02)
An efficient catalytic synthesis of unsaturated ethers by carbene insertion (with diazoesters as carbene precursors) into the OH bond of unsaturated alcohols is reported.The regioselectivity for the OH insertion is high.However, depending on the catalyst counter-ions and the diazoester alkoxy group, addition to the unsaturated centre can be promoted to some extent, yielding then cyclopropyl and cyclopropenyl carbinols.The mechanistic aspects of the reactions are discussed.
