42427-61-2Relevant academic research and scientific papers
An efficacious method for the halogenation of β-dicarbonyl compounds under mildly acidic conditions
Meketa, Matthew L.,Mahajan, Yogesh R.,Weinreb, Steven M.
, p. 4749 - 4751 (2005)
A variety of 1,3-diketones, β-ketoesters and malonates can be chlorinated in high yields using sodium hypochlorite in a 5:2 mixture of acetone/acetic acid at 0°C for 1 h. Similarly, bromination of these dicarbonyl substrates can be accomplished under the same conditions using sodium hypobromite.
Oxidative Chlorination of Activated Methylene Compounds with Sodium Chloride
Umland, Klaus-Daniel,Mayer, Camilla,Kirsch, Stefan F.
, p. 813 - 816 (2014)
An operationally simple protocol for the direct chlorination of 1,3-dicarbonyls (and related compounds such as α-cyano A?ketones) is described. The procedure relies on mild conditions using IBX-SO3K as the stoichiometric oxidizing agent and the
Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate
Chong, Siying,Su, Yingpeng,Wu, Lili,Zhang, Weigang,Ma, Junyan,Chen, Xiaowei,Huang, Danfeng,Wang, Ke-Hu,Hu, Yulai
, p. 1359 - 1370 (2016/05/02)
Trimethylchlorosilane was used as chlorine source for the α-chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate as oxidant at room temperature. The reaction allows the selective synthesis of α-monochlorinated products from different kinds of 1,3-dicarbonyl compounds in good yield. The potential possibility of this conversion for bromination has also been investigated.
Iron(iii) chloride hexahydrate-promoted selective hydroxylation and chlorination of benzyl ketone derivatives for the construction of hetero-quaternary scaffolds
Chen, Tao,Peng, Rui,Hu, Wenxin,Zhang, Fu-Min
supporting information, p. 9859 - 9867 (2016/10/31)
A novel and tunable α-hydroxylation/α-chlorination of benzyl ketone derivatives has been developed for the construction of hetero-quaternary carbon centers by iron(iii) chloride hexahydrate mediated selective transformations through the application of dif
