4243-20-3

Basic information

• Product Name: 3-chloro-N-methyl-N-nitrosoaniline
• CAS NO: 4243-20-3
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.5963
• Mol File: 4243-20-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 307.4°C at 760 mmHg
• Flash Point: 139.7°C
• Density: 1.23g/cm³
• Vapor Pressure: 0.000727mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 3-chloro-N-methyl-N-nitrosoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-methyl-N-nitrosoaniline(4243-20-3)
• EPA Substance Registry System: 3-chloro-N-methyl-N-nitrosoaniline(4243-20-3)

Safety Data

• Hazardous Substances Data: 4243-20-3(Hazardous Substances Data)

Upstream product

• 108-42-9 3-chloro-aniline 
• 77-78-1 dimethyl sulfate 
• 7006-52-2 3-chloro-N-methylaniline 
• 110-46-3 isopentyl nitrite 
• 6848-13-1 3-chloro-N,N-dimethylaniline 
• 509-14-8 tetranitromethane 
• 110-86-1 pyridine 
• 64-17-5 ethanol 

Downstream Products

• 7006-52-2 3-chloro-N-methylaniline 
• 1416897-59-0 (E)-methyl 3-(2-chloro-6-(methyl(nitroso)amino)phenyl)acrylate 
• 1416897-60-3 (E)-methyl 3-(4-chloro-2-(methyl(nitroso)amino)phenyl)acrylate 
• 1416897-85-2 (E)-methyl 3-(2-chloro-6-(methylamino)phenyl)acrylate 
• 1416897-86-3 (E)-methyl 3-(4-chloro-2-(methylamino)phenyl)acrylate 
• 90084-83-6 N-methyl-N-(m-chlorophenyl)hydrazine 

Relevant articles and documents

Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation

Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.

Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles

Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is

Cp?Rh(iii) catalyzed: Ortho -halogenation of N -nitrosoanilines by solvent-controlled regioselective C-H functionalization

We present a novel, efficient, and regioselective method for the rhodium-catalyzed direct C-H ortho-halogenation of anilines that involves a removable N-nitroso directing group. This method featured mild reaction conditions, wide substrate scope, good functional group tolerance and satisfactory yields. To maintain the high ortho-regioselectivity and conversion, increasing the steric hindrance of the solvent was critical. Preliminary mechanistic studies suggest that C-H activation may be involved in the rate-determining step.