4248-13-9

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-phenyl-2-(phenylamino)-
• CAS NO: 4248-13-9
• Molecular Formula: C20H15N3O
• Molecular Weight: 313.359
• Mol File: 4248-13-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-phenyl-2-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-phenyl-2-(phenylamino)-(4248-13-9)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-phenyl-2-(phenylamino)-(4248-13-9)

Safety Data

• Hazardous Substances Data: 4248-13-9(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 5416-30-8 N,N'-diphenyl-S-methyl isothiourea 
• 201230-82-2 carbon monoxide 
• 615-43-0 2-iodophenylamine 
• 622-16-2 1,3-Diphenylcarbodiimide 
• 62-53-3 aniline 
• 134-20-3 2-carbomethoxyaniline 
• 102-08-9 N,N-diphenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 1218906-34-3 N-(2-iodophenyl)-N'-phenyldicarbodiimide 
• 13939-06-5 molybdenum hexacarbonyl 
• 87-25-2 2-ethoxycarbonylaniline 

Downstream Products

• 57266-65-6 3-phenyl-hexahydro-quinazoline-2,4-dione 

Relevant articles and documents

RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides

The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.

Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation

A new, efficient and practical synthesis of quinazolin-4(3H)-ones is reported via molybdenum-mediated cyclocarbonylation using microwave irradiation. These methods allow access to a wide range of quinazolin-4(3H)-ones in reasonable yields without the need for gaseous carbon monoxide and palladium catalysts. A range of reactions illustrating the wide scope of this chemistry was carried out and all proceeded in reasonable yields.