42509-22-8

Upstream product

• 19711-92-3 phenanthridine-6-carboxylic acid 
• 24451-19-2 N-(2-[1,1‘-biphenyl])-oxanilic acid ethyl ester 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 90-41-5 2-phenylaniline 
• 39950-19-1 ethyl [1,1‘-biphenyl]-2-ylglycinate 
• 3128-77-6 2-isocyanobiphenyl 
• 4114-31-2 ethylhydrazine carboxylate 
• 1221966-54-6 ethyl 2-azido-2-(biphenyl-2-yl)acetate 
• 126430-66-8 2-phenanthridin-6-yl-propane-1,3-diol 
• 3955-65-5 6-methylphenanthridine 

Relevant academic research and scientific papers

Metal-free tandem carbene N-H insertions and C-C bond cleavages

A metal-free C-H [5 + 1] annulation reaction of 2-arylanilines with diazo compounds has been achieved, giving rise to two types of prevalent phenanthridines via highly selective C-C cleavage. Compared to the simple N-H insertion manipulation of diazo, this method elegantly accomplishes a tandem N-H insertion/SEAr/C-C cleavage/aromatization reaction, and the synthetic utility of this new transformation is exemplified by the succinct syntheses of trisphaeridine and bicolorine alkaloids. This journal is

Phenanthridine compound and synthesis method thereof (by machine translation)

The invention discloses a phenanthridine compound and a synthesis method thereof which, are separated and purified by adding an arylamine compound and a, diazo carbonyl compound to a solvent in an oxygen environment to obtain. the phenanthridine compound. (by machine translation)

Radical arylalkoxycarbonylation of 2-isocyanobiphenyl with carbazates: Dual C-C bond formation toward phenanthridine-6-carboxylates

A sequential oxidative radical alkoxycarbonylation and aromatization of 2-isocyanobiphenyl with carbazates was developed to furnish phenanthridine-6- carboxylates. Various functional groups such as methoxy, chloro, fluoro, trifluoromethoxy, and trifluoromethyl groups were tolerated well under the reaction conditions. The sequential radical addition-cyclization strategy represents a practical route to access phenanthridine-6-carboxylates.

Tetrabutylammonium iodide-catalyzed radical alkoxycarbonylation of 2-isocyanobiphenyls with carbazates: Synthesis of phenanthridine-6-carboxylates

A practical and environmentally friendly strategy for generating alkoxycarbonyl radicals from readily available carbazates under metal-free conditions has been developed. In the presence of tetrabutylammonium iodide and tert-butyl hydroperoxide, 2-isocyanobiphenyls smoothly underwent radical alkoxycarbonylation with carbazates to afford phenanthridine-6-carboxylates.

Synthesis of 6-substituted phenanthridines by metal-free, visible-light induced aerobic oxidative cyclization of 2-isocyanobiphenyls with hydrazines

Irradiation of hydrazines with visible-light in the presence of organic dye eosin B generates various types of functional radicals, which are trapped by 2-isocyanobiphenyls to give 6-substituted phenanthridines. the Partner Organisations 2014.

Generation of iminyl copper species from α-azido carbonyl compounds and their catalytic C-C bond cleavage under an oxygen atmosphere

Figure presented A copper-catalyzed reaction of α-azidocarbonyl compounds under an oxygen atmosphere is reported where nitriles are formed via C-C bond cleavage of a transient iminyl copper intermediate. The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from α-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O2 was found to be incorporated into the β-carbon fragment as a carboxylic acid.

METHOD FOR PRODUCING BENZAZEPINONE

It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild conditions. The present invention provides a method for producing a benzazepinone or a salt thereof, which comprises opening a ring of an isoquinoline derivative and subsequently converting the thus generated amine into a benzazepinone through lactamization reaction.