42520-99-0Relevant academic research and scientific papers
A convenient one-pot preparation of N-substituted 4-phenylpiperidines
Asano, Shigehiro,Ban, Hitoshi
, p. 183 - 188 (2008/09/20)
N-Substituted 4-phenylpiperidines were readily synthesized by one-pot cyclization of diols with amines via bis-triflate intermediates. The new synthesis under mild conditions gave various N-substituted 4-phenylpiperidines in moderate to good yields.
Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine
Mercer, Susan L.,Hassan, Hazem E.,Cunningham, Christopher W.,Eddington, Natalie D.,Coop, Andrew
, p. 1160 - 1162 (2007/10/03)
P-Glycoprotein (P-gp) is an efflux transporter which is up-regulated at the blood-brain barrier in both morphine- and oxycodone-tolerant rats. Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-gp, suggesting that up-regulation of P-gp may contribute to the development of central tolerance to opioids. The studies herein focus on the development of SAR for P-gp substrate activity in the meperidine series of compounds, and show that a meperidine analog of greater potency, N-phenylbutyl-N-normeperidine, has low activity as a P-gp substrate and has the potential to be utilized as a tool to study the contribution of P-gp to the development of central tolerance to opioids.
Facile Synthesis of N-Substituted-4-cyano-4-phenylpiperidines via Phase-Transfer Catalysis
Thompson, Doug,Reeves, Perry C.
, p. 771 - 772 (2007/10/02)
Phenylacetonitrile can be condensed with N-substituted-bis(2-chloroethyl)amines in aqueous sodium hydroxide solution to produce N-substituted-4-cyano-4-phenylpiperidines.Hexadecyltributylphosphonium bromide is an effective catalyst for this phase-transfer reaction.
