42526-65-8

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 504-63-2 trimethyleneglycol 
• 20627-73-0 1-(dimethoxymethyl)-2-nitrobenzene 

Downstream Products

• 26908-34-9 N-(2-(1,3-dioxolan-2-yl))phenylamine 
• 1345042-84-3 N-(2-formylphenyl)-3-(furan-2-carbonyl)thiazolidine-4-carboxamide 
• 1345042-57-0 N-(2-formylphenyl)-1-(furan-2-carbonyl)pyrrolidine-2-carboxamide 
• 1345042-47-8 N-(2-(2-formylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivalamide 
• 1345042-46-7 N-(2-formylphenyl)-2-(N-(furan-2-ylmethyl)phenylsulfonamido)acetamide 
• 1345042-45-6 N-benzyl-N-(2-(2-formylphenylamino)-2-oxoethyl)-1-methyl-1H-pyrrole-2-carboxamide 
• 1345042-44-5 N-benzyl-N-(2-(2-formylphenylamino)-2-oxoethyl)thiophene-2-carboxamide 
• 1345042-43-4 N-benzyl-N-(2-(2-formylphenylamino)-2-oxoethyl)furan-2-carboxamide 
• 1345042-79-6 N-(2-(1,3-dioxolan-2-yl)phenyl)-2-(furan-2-ylmethylamino)acetamide 
• 1345042-78-5 N-(2-(1,3-dioxolan-2-yl)phenyl)-2-(benzylamino)acetamide 
• 1345042-42-3 N-(2-(1,3-dioxolan-2-yl)phenyl)-2-bromoacetamide 

Relevant academic research and scientific papers

Practical acetalization and transacetalization of carbonyl compounds catalyzed by recyclable PVP-I

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields.

Direct anodic (thio)acetalization of aldehydes with alcohols (thiols) under neutral conditions, and computational insight into the electrochemical formation of the acetals

A versatile protocol for the production of acetals/thioacetals by means of direct electrochemical oxidation is developed here under neutral conditions, providing (thio)acetals with good functional group tolerance and a wide scope for both aldehydes and (thio)alcohols. DFT calculations reveal that direct electron transfer from the anode plays a key role in carbonyl activation during this acid free acetalization process.

Synthesis and characterization of a tetracationic acidic organic salt and its application in the synthesis of bis(indolyl)methanes and protection of carbonyl compounds

A new tetracationic acidic organic salt (TCAOS) based on DABCO was prepared, characterized and applied as an eco-friendly, powerful and reusable catalyst for the synthesis of bis(indolyl)methanes from indoles and carbonyl compounds in water with high turnover frequency (TOF). Also, this catalyst was successfully applied for acetalization of carbonyl compounds with diols under solvent-free conditions.

Highly efficient and chemoselective acetalization of carbonyl compounds catalyzed by new and reusab e zirconyl triflate, zr0(0tf)2

Various types of aromatic aldehydes were efficiently converted to their corresponding 1,3-dioxanes and 1,3-dioxolane with 1,3-propanediol and ethylene glycol, respectively, in the presence of catalytic amount of ZrO(OTf) 2 in acetonitrile at room temperature. The catalyst can be reused several times without loss of its catalytic activity. Very short reaction times, selective acetalization of aromatic aldehydes in the presence of aliphatic aldehydes and ketones, very mild reaction conditions, reusability of the catalyst, and easy workup are noteworthy advantages of this method.