20627-73-0

Usage

InChI:InChI=1/C9H11NO4/c1-13-9(14-2)7-5-3-4-6-8(7)10(11)12/h3-6,9H,1-2H3

Upstream product

• 67-56-1 methanol 
• 552-89-6 2-nitro-benzaldehyde 
• 616-42-2 dimethylsulfite 
• 149-73-5 trimethyl orthoformate 
• 124-41-4 sodium methylate 
• 7647-01-0 hydrogenchloride 
• 77-78-1 dimethyl sulfate 
• 3284-77-3 1-(dichloromethyl)-2-nitrobenzene 

Downstream Products

• 61161-26-0 o-carbomethoxynitrosobenzene 
• 17049-65-9 2-phenyl-1,2-dihydro-3H-indazol-3-one 
• 51284-79-8 Bis-(2-dimethoxymethyl-phenyl)-diazene 
• 51284-78-7 N,N'-Bis-(2-dimethoxymethyl-phenyl)-diazene N-oxide 
• 253-82-7 quinazoline 
• 118-92-3 anthranilic acid 
• 552-89-6 2-nitro-benzaldehyde 
• 17418-09-6 4-hydroxy-4-(2-nitrophenyl)butan-2-one 
• 700-46-9 4-methylquinazoline 
• 51284-80-1 3-Dimethoxymethyl-2-(2-dimethoxymethyl-phenylazo)-phenol 
• 1361926-28-4 ethyl 4-methyl-2-oxo-4-(o-nitrophenyl)but-3-enoate 
• 48140-35-8 2-(2-nitrophenyl)-1,3-dioxolane 
• 42526-65-8 2-(2-nitrophenyl)-1,3-dioxane 
• 103471-61-0 ({2-{2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-[methoxy-(2-nitro-phenyl)-methyl]-phenyl}-carboxymethyl-amino)-acetic acid 

Relevant academic research and scientific papers

Intermediate substance with acid degradation function, preparation method of same, and polymerizable monomer prepared from intermediate substance

The invention discloses an intermediate substance with an acid degradation function and a preparation method of same; whereinthe preparation method of the intermediate substance comprises the following steps: dissolving 2-nitrobenzaldehyde in a proper amount of dichloromethane, if the reaction substance is cinnamyl aldehyde, mixing the substance with trimethyl orthoformate without the help of a dichloromethane solvent with hafnium trifluoromethanesulfonate as a catalyst; then under the condition of room temperature, performing magnetic stirring to obtain the target substance in a very short time. According to the invention, the defects of time consumption, energy consumption, solvent consumption and the like caused by adopting p-toluenesulfonic acid as a catalyst for preparing the substance traditionally are avoided, and the prepared substance has an acid degradation function. Corresponding 2-nitrobenzaldehyde or cinnamyl aldehyde can be obtained through acid degradation, and in addition, the intermediate substance provides convenience for subsequent preparation of polymerizable monomers with an acid degradation function.

Practical acetalization and transacetalization of carbonyl compounds catalyzed by recyclable PVP-I

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields.

Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

Acetalization of aldehydes is an area of great importance in Organic Chemistry for both synthetic and biological puproses. Herein, we report a mild, inexpensive and green photochemical protocol, where Schreiner's thiourea (N,N′-bis[3,5-bis(trifluoromethyl)-phenyl]-thiourea) is utilized as the catalyst and cheap household lamps as the light source. A variety of aromatic and aliphatic aldehydes were converted into acetals in good to high yields (23 examples, 36-96% yield) and an example of the synthesis of a cyclic acetal is provided. The reaction mechanism was also studied.

Preparation method of acetal or ketal compound

The invention discloses a preparation method of an acetal or ketal compound. The preparation method comprises the following steps: oscillating aldehyde or ketone, alcohol and a catalyst at 60 DEG C, and carrying out post-treatment after the reaction is finished to obtain the acetal compound, wherein the catalyst comprises alpha-chymotrypsin, the aldehyde or ketone has a structure represented by acompound A, R1 and R2 are respectively and independently selected from aryl, H and alkyl, the alcohol has a structure represented by a compound B, and R3 is selected from saturated alkane. The preparation method provided by the invention is catalyzed by alpha-chymotrypsin, is mild in reaction condition, simple in operation process, low in cost and environment-friendly, and has popularization and application values.

α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.

Nickel-Catalyzed Chemoselective Acetalization of Aldehydes With Alcohols under Neutral Conditions

A molecularly defined NiII-complex catalyzing the chemoselective acetalization of aldehydes with alcohols under neutral conditions is reported. The reaction is general, efficient and showed a wide substrate scope (including aliphatic aldehydes) as well as excellent functional group tolerance. Reusability of the present nickel catalyst is also demonstrated.

O-nitrobenzene diacetal ethyl diacrylate, preparation method thereof and application of o-nitrobenzene diacetal ethyl diacrylate to crosslinking agent with double degradation performances

The invention discloses o-nitrobenzene diacetal ethyl diacrylate, a preparation method thereof and an application of the o-nitrobenzene diacetal ethyl diacrylate to a crosslinking agent with double degradation performances. The compound takes o-nitrobenzaldehyde, trimethyl orthoformate and hydroxyethyl acrylate as starting materials, and a target product is obtained by two-step substitution reaction. The compound has the advantages that the preparation method of the compound is simple, operation is convenient, raw materials are easily obtained, and the compound can be degraded under the conditions of illumination and acid.

Ru(II)-functionalized SBA-15 as highly chemoselective, acid free and sustainable heterogeneous catalyst for acetalization of aldehydes and ketones

Combining electron deficient Ru(II) coordination sites with organofunctionalized SBA-15, (L)Ru(II)@SBA-15, result in a mild, neutral, water scavenger free and chemo-selective acetalization catalyst for cyclic/acyclic acetals. Vacant coordination sites of ruthenium in (L)Ru(II)@SBA-15 activates protecting groups as well as reactants simultaneously and restricts the reverse acetalization reaction. Synthesized (L)Ru(II)@SBA-15 catalyst has been thoroughly characterized and act as competitive catalyst compared to conventional acid catalysts. (L)Ru(II)@SBA-15 performs high catalytic activity as well as selectivity within 20 min with high TOF. The catalyst can be recycled and reaction parameters are optimized.

Phosphorylated Polyacrylonitrile Fibers as an Efficient and Greener Acetalization Catalyst

A novel solid acid catalyst (PANEAPF) is developed by immobilization of phosphoric acid on polyacrylonitrile fiber through covalent bonding. Various characterization techniques such as elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), etc. are utilized to confirm the successful grafting and the stability of the fiber catalysts during application. PANEAPF shows high catalytic activity in the acetalization of aldehydes owing to the high utilization efficiency of its functionalized acid sites. In addition, the strong polarity micro-environment in the surface layers of PANEAPF make it highly suitable for catalytic application in both water and alcohol. Furthermore, the fiber catalyst can be applied to the acetalization of aldehydes in a continuous-flow process at room temperature, and shows excellent reactivity and superior recyclability (over 20 times). The many advantages of PANEAPF such as simple preparation, convenient regulation of acid amount, high durability, and eco-friendly process make it very attractive for fixed-bed reactors in the chemical industry.

Zeolite nanofiber assemblies as acid catalysts with high activity for the acetalization of carbonyl compounds with alcohols

Zeolite nanofiber assemblies (HNB-MOR) as efficient heterogeneous catalysts for the formation of a range of acetals in good yields. The mesoporosity of HNB-MOR benefits mass transfer, and the strong acidic sites on HNB-MOR facilitate acetalization activity. The catalyst can be reused 10 times without loss of activity.