26908-34-9Relevant articles and documents
Activated Self-Resolution and Error-Correction in Catalytic Reaction Networks**
Schaufelberger, Fredrik,Ramstr?m, Olof
, p. 10335 - 10340 (2021/05/07)
Understanding the emergence of function in complex reaction networks is a primary goal of systems chemistry and origin-of-life studies. Especially challenging is to create systems that simultaneously exhibit several emergent functions that can be independently tuned. In this work, a multifunctional complex reaction network of nucleophilic small molecule catalysts for the Morita-Baylis-Hillman (MBH) reaction is demonstrated. The dynamic system exhibited triggered self-resolution, preferentially amplifying a specific catalyst/product set out of a many potential alternatives. By utilizing selective reversibility of the products of the reaction set, systemic thermodynamically driven error-correction could also be introduced. To achieve this, a dynamic covalent MBH reaction based on adducts with internal H-transfer capabilities was developed. By careful tuning of the substituents, rate accelerations of retro-MBH reactions of up to four orders of magnitude could be obtained. This study thus demonstrates how efficient self-sorting of catalytic systems can be achieved through an interplay of several complex emergent functionalities.
Synthesis and selective 2H-, 13C-, and 15N-labeling of the Tau protein binder THK-523
Neumann, Karoline T.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
, p. 30 - 35 (2017/01/17)
A new synthetic route to the Tau binder, THK-523, is disclosed herein, which can easily be adapted to 13C- and D-isotope labeling. The synthesis proceeds via two key reactions, namely, a Pd-catalyzed carbonylative Sonogashira coupling and a red
Photoassisted diversity-oriented synthesis: Intramolecular cycloadditions of photogenerated azaxylylenes with oxazole pendants, and subsequent postphotochemical multicomponent modifications
Kumar, N. N. Bhuvan,Kutateladze, Andrei G.
supporting information, p. 460 - 463 (2016/02/18)
Photogenerated aza-o-xylylenes undergo intramolecular cycloaddition reactions to tethered oxazoles, with primary photoproducts featuring a reactive cyclic imine moiety suitable for multicomponent postphotochemical transformations. For example, the reactio