58628-98-1

Usage

Uses

Used in Organic and Polymer Chemistry:
4,5-Dimethyl-2-oxazolidinone is used as a general solvent in organic and polymer chemical reactions for its ability to dissolve a wide range of compounds, facilitating various synthesis processes and improving reaction efficiency.
Used in Food Industry:
In the food industry, 4,5-Dimethyl-2-oxazolidinone plays a role in maintaining fruit and food quality, as it can influence ripening and deterioration processes. Its use helps in extending the shelf life of perishable items and ensuring better preservation of their nutritional and sensory attributes.
Used in Pharmaceutical Industry:
4,5-Dimethyl-2-oxazolidinone is also utilized in the pharmaceutical industry as a solvent for various drug formulations, particularly those requiring a stable and non-reactive medium. Its properties make it suitable for use in the development of new drugs and drug delivery systems.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, 4,5-Dimethyl-2-oxazolidinone is employed as an ingredient in various formulations, such as creams, lotions, and shampoos, due to its ability to improve the solubility of other components and enhance product performance.
Overall, 4,5-Dimethyl-2-oxazolidinone is a versatile compound with applications in multiple industries, including organic and polymer chemistry, food, pharmaceuticals, and cosmetics, where it contributes to improved product quality, stability, and performance.

InChI:InChI=1/C5H9NO2/c1-3-4(2)8-5(7)6-3/h3-4H,1-2H3,(H,6,7)

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Relevant academic research and scientific papers

(Enantio)selective Hydrogen Autotransfer: Ruthenium-Catalyzed Synthesis of Oxazolidin-2-ones from Urea and Diols

A novel strategy for the synthesis of oxazolidin-2-ones from vicinal diols and urea is described. In this heterocycle synthesis, two different C?O and C?N bonds are sequentially formed in a domino process consisting of nucleophilic substitution and alcohol amination. The use of readily available starting materials and the good atom economy render this process environmentally benign. While this transformation is already highly chemo- and regioselective, we also developed the first asymmetric version of this method using (R)-(+)-MeO-BIPHEP as the chiral ligand.

Aluminium-Catalysed Oxazolidinone Synthesis and their Conversion into Functional Non-Symmetrical Ureas

An efficient and practical aluminium-catalysed approach towards a range of functional oxazolidinones is reported. The method is based on cheap and readily available starting materials including terminal and internal (bicyclic) epoxides and phenyl carbamate. The oxazolidinones serve as highly useful synthons for the high yield preparation of non-symmetrical ureas by nucleophilic ring-opening affording the targeted urea compounds with excellent functional group diversity, high regioselectivity and isolated yields up to >99%.

Synthesis of 2-oxazolidinones from CO2 and 1,2-aminoalcohols catalyzed by n-Bu2SnO

The dehydrative condensation of 1,2-aminoalcohols with CO2 is found to proceed in NMP as solvent; 2-oxazolidinones are obtained in the yields of 53-94% when a commercially available tin compound, n-Bu2SnO is used as catalyst.

A short diastereo- and enantioselective synthesis of cis-4,5-disubstituted oxazolidin-2-ones

The asymmetric synthesis of cis-4,5-disubstituted oxazolidin-2-ones is described. Following a four step reaction sequence of α-alkylation, 1,2-addition with subsequent carbamate protection, cyclization and concluding with cleavage of the auxiliary the title compounds are obtained in moderate yields and in excellent diastereo- and enantiomeric excesses (de = 88 - > 96%, ee > 96%).