425622-44-2Relevant academic research and scientific papers
A convenient synthesis of C-22 and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins.
Betancor, Carmen,Freire, Raimundo,Perez-Martin, Ines,Prange, Thierry,Suarez, Ernesto
, p. 1295 - 1297 (2002)
A simple transformation of the eight-carbon side chain of a natural spirostan sapogenin into the cephalostatin north 1 spiroketal moiety is described. This methodology, based on an intramolecular hydrogen abstraction reaction promoted by alkoxy radicals,
Hydrogen atom transfer methodology for the synthesis of C-22, C-23, and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins
Betancor, Carmen,Freire, Raimundo,Pérez-Martín, Inés,Prangé, Thierry,Suárez, Ernesto
, p. 2803 - 2814 (2007/10/03)
A simple synthesis of all eight C-22, C-23, and C-25 diastereoisomers of the cephalostatin north 1 side chain has been accomplished from (25R)-5α-spirostan-3β-ol (tigogenin). The synthesis involves selective hydroxylations at C-23 and C-25 and reductive o
