A convenient synthesis of C-22 and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins.

DOI: 10.1021/ol025580e

Source and publish data:

Organic letters p. 1295 - 1297 (2002)

Update date:2022-08-05

Topics:

Authors:

Betancor, Carmen

Freire, Raimundo

Perez-Martin, Ines

Prange, Thierry

Suarez, Ernesto

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Article abstract of DOI:10.1021/ol025580e

A simple transformation of the eight-carbon side chain of a natural spirostan sapogenin into the cephalostatin north 1 spiroketal moiety is described. This methodology, based on an intramolecular hydrogen abstraction reaction promoted by alkoxy radicals,

Full text of DOI:10.1021/ol025580e

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