42564-43-2Relevant academic research and scientific papers
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity
Wang, Haishan,Yu, Niefang,Song, Hongyan,Chen, Dizhong,Zou, Yong,Deng, Weiping,Lye, Pek Ling,Chang, Joyce,Ng, Melvin,Sun, Eric T.,Sangthongpitag, Kanda,Wang, Xukun,Wu, Xiaofeng,Khng, Hwee Hoon,Fang, Lijuan,Goh, Siok Kun,Ong, Wai Chung,Bonday, Zahid,Stuenkel, Walter,Poulsen, Anders,Entzeroth, Michael
scheme or table, p. 1403 - 1408 (2009/10/15)
A series of N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides were designed and synthesized as novel HDAC inhibitors. General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene group an
VIRAL POLYMERASE INHIBITORS
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Page/Page column 51, (2008/06/13)
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.
VIRAL POLYMERASE INHIBITORS
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Page 123, (2010/02/07)
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
