425644-03-7

Upstream product

• 112663-43-1 3-(tert-butoxycarbonylamino)propyl methanesulfonate 
• 425644-02-6 N-(2-nitrobenzenesulfonyl)-N'-(benzyloxycarbonyl)-1,4-diaminobutane 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 116861-31-5 tert-butyl N-(3-chloropropyl)carbamate 
• 62146-62-7 (4-aminobutyl)carbamic acid benzyl ester 
• 349553-74-8 N-(2-nitrobenzenesulfonyl)-1,4-diaminobutane hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 85503-20-4 N,N-bis(tert-butoxycarbonyl)spermidine 
• 80926-69-8 N⁸-benzyloxycarbonyl-N¹,N⁴-di-tert-butoxycarbonylspermidine 
• 138093-86-4 N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-methyl-L-α,β-diaminopropionylglycyl-N⁵,N⁸-bis(tert-butoxycarbonyl)spermidine 
• 103493-33-0 N¹-tert-butyloxycarbonyl-N⁴,N⁸-dibenzyloxycarbonylspermidine 
• 153815-25-9 N⁸-benzyloxycarbonyl-N¹-tert-butoxycarbonylspermidine 

Relevant academic research and scientific papers

Total Synthesis and Biological Evaluation of Paenilamicins from the Honey Bee Pathogen Paenibacillus larvae

Paenilamicins are a group of complex polycationic peptide secondary metabolites with antibacterial and antifungal activities produced by the devastating honey bee brood pathogen Paenibacillus larvae causing the lethal brood disease American Foulbrood (AFB

An efficient synthesis of orthogonally protected spermidine

A major problem in the use of spermidine for the synthesis of biologically interesting compounds is the selective orthogonal protection of the three different amino groups. Our approach is based on the Fukuyama reaction, starting from putrescine and 3-amino-l-propanol and affording N8-benzyloxycarbonyl- N1-tert-butyloxycarbonyl- N4-(2-nitrobenzenesulfonyl)spermidine (5) in 5 steps in high yield.