42565-78-6

Upstream product

• 79-38-9 Chlorotrifluoroethylene 
• 98-86-2 acetophenone 
• 683-78-3 trifluorovinyllithium 
• 690-01-7 fluoro ethinylsodium 
• 1234972-68-9 3,4,4-trifluoro-1-triethylsiloxy-1-phenyl-but-3-ene 
• 79035-75-9 1,2-bis(dimethylphenylsilyl)-1,1,2,2-tetrafluoroethane 
• 107-02-8 acrolein 
• 186824-44-2 1,2-bis(trimethylsilyl)-1,1,2,2-tetrafluoroethane 

Downstream Products

• 111303-13-0 ((E)-2,3,3-Trifluoro-1-methyl-propenyl)-benzene 
• 111303-12-9 ((Z)-2,3,3-Trifluoro-1-methyl-propenyl)-benzene 
• 93119-83-6 (E)-<3,4,4,4-Tetrafluoro-2-butenyl>benzene 
• 93119-77-8 (Z)-<3,4,4,4-Tetrafluoro-2-butenyl>benzene 
• 55305-85-6 (Z)-2-Fluoro-3-phenyl-but-2-enoic acid diethylamide 
• 55305-84-5 (Z)-2-Fluoro-3-phenyl-but-2-enoic acid ethyl ester 
• 708-84-9 α-Fluor-β-phenyl-crotonsaeure 
• 58041-00-2 (Z)-2-fluoro-3-phenylacrylaldehyde 
• 55305-79-8 (Z)-2-Fluoro-3-phenyl-but-2-enoyl fluoride 

Relevant academic research and scientific papers

1,2-Bis(dimethylphenylsilyl)tetrafluoroethane. Application to the trifluorovinylation and tetrafluoroethylenation of carbonyl compounds

The reaction of 1,2-bis(dimethylphenylsilyl)tetrafluoroethane with a small excess of benzaldehyde in the presence of the promoter gave the trifluorovinylated product, 1,1,2-trifluoro-3-phenylpropen-3-ol, selectively. The tetrafluoroethylenated product, 2,2,3,3-tetrafluoro-1,4-diphenylbutane-1,4-diol, was also obtained in benzaldehyde solvent or at low temperatures.

On the reactions of trifluorovinylsilanes with aromatic ketones - Expected and some unexpected results

The reactions of aromatic ketones with trialkyl(trifluorovinyl)silanes in the presence of fluoride ions were studied. The conditions for the selective addition of trialkyl(trifluorovinyl)silanes to the carbonyl function of aromatic ketones in the presence

Preparation of and fluoroalkylation with (chlorodifluoromethyl)trimethylsilane, difluorobis(trimethylsilyl)methane, and 1,1,2,2-tetrafluoro-1,2-bis(trimethylsilyl)ethane

CF2BrCl reacts with aluminum/N-methylpyrrolidinone in the presence of chlorotrimethylsilane to give Me3SiCF2Cl in high yield. Similarly, CF2Br2 gives Me3SiCF2Br with bromotrimethylsilane. Chlorodifluoromethylation of aldehydes using Me3SiCF2Cl and a catalytic amount of TBAF in polar solvents occurs at room temperature, providing difluoromethylated alcohols in two steps. Electroreduction of Me3SiCF2Cl in the presence of chlorotrimethylsilane gives Me3SiCF2SiMe3 (anion-derived product) and Me3SiCF2CF2SiMe3 (radical-derived product). Using THF/HMPA strongly favors the former, whereas THF/TDA-1 (tris(3,6-dioxaheptyl)amine) the latter. Me3SiCF2SiMe3 difluoromethylates aldehydes acting as a difluoromethylene dianion ('CF22-'/equivalent), whereas Me3SiCF2CF2SiMe3 acts at room temperature as an in situ source for the perfluorovinyl anion (due to β-elimination of fluorotrimethylsilane). However, at low temperature the elimination pathway is suppressed and tetrafluoroethylene dianion ('-CF2CF2-'/equivalent) behavior is observed. The structure of Me3SiCF2CF2SiMe3 was analyzed by X-ray diffraction. All of the studied fluoroalkylating reagents are moisture- and air-stable and can be readily obtained from a single convenient precursor (CF2BrCl).

Hydrogen Fluoride/Tetrahydrofuran as a Fluorinating Medium. A General Synthesis of 1,1,1,2-Tetrafluoro-2-alkenes

A general and simple two step synthesis of 1,1,1,2-tetrafluoro-2-alkenes is presented.The key step is the rearrangement-conversion of 1,1,2-trifluoro-1-alken-3-ols under the influence of hydrogen fluoride/tetrahydrofuran (5:1) as a fluorinating medium.