4260-40-6

Usage

Main Properties

Also known as 3-phenylbarbituric acid
Derivative of the barbituric acid family
Used in pharmaceutical production
Acts as a central nervous system depressant

Specific Content

Used in the synthesis of sedative and hypnotic drugs
Has potential anticonvulsant properties
Has potential neuroprotective properties
Attracts interest in medical and research fields for potential applications in neurological and psychiatric disorders
Can be used as a sedative or anesthetic

Upstream product

• 37804-34-5 2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 
• 723-76-2 2,6-dioxo-1-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid 
• 5759-75-1 6-chloro-3-phenylpyrimidine-2,4(1H,3H)-dione 
• 64-10-8 phenyl carbamate 
• 122-51-0 orthoformic acid triethyl ester 
• 15018-50-5 1-phenyl-pyrimidine-2,4,6-trione 
• 109853-39-6 (1S,2S,3R,4R)-3-Amino-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid phenylamide 
• 18280-60-9 (2,5-dioxo-1-phenyl-imidazolidin-4-ylidene)-acetic acid 
• 731-54-4 (Z)-ethyl 2-(2,5-dioxo-1-phenylimidazolidin-4-ylidene)acetate 
• 103-71-9 phenyl isocyanate 
• 302967-61-9 ethyl 2,4-dioxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Flash vacuum pyrolysis (fvp) of some hexahydroquinazolin-4(1H)-ones

Some cis/trans-2-thioquinazolin-4-ones and their 2,4-dione analogs were subjected to flash vacuum pyrolysis. The cis- and trans-thio compounds reacted at lower temperatures than the cis- and trans-dioxo analogs, showing a lower thermal stability. All of these compounds afforded similar reactions: ring opening to the corresponding iso(thio)cyanate, the loss of H{radical dot} and {radical dot}NCS to form three isomeric cyclohexadienes and then aromatization to form the corresponding benzamide. The cis-dioxo compound also underwent a competitive retro Diels-Alder (RDA) reaction to form 3-phenylpyrimidine-2,4(1H,3H-dione(3-phenyluracil)) and butadiene. Kinetic measurements of the ring opening reaction supported a concerted β-elimination as the most probable mechanism.

Solid-phase synthesis of 4(1H)-quinolone and pyrimidine derivatives based on a new scaffold - Polymer-bound cyclic malonic acid ester

An efficient method for the preparation of polymer-bound cyclic malonic acid ester starting from Merrifield resin has been developed. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with

ISOLATION OF NEW CHLORINATED REGIOISOMERS OF MONO N-SUBSTITUTED URACIL DERIVATIVES AND SYNTHESIS OF 3-SUBSTITUTED 8-PHENYLPYRIMIDO-1,2,4-TRIAZINE-5,7(6H,8H)-DIONES

A variety of fervenulin type products, 3-substituted 8-phenylpyrimido-1,2,4-triazine-5,7(6H,8H)-diones (18a-i), were synthesized by nitrosative or nitrative cyclization of the aldehyde hydrazones (17a-i) derived from 6-(1-methylhydrazino)-1-phenyluracil (16) with aliphatic as well as aromatic aldehydes.The compound (16) was prepared by the reaction of 6-chloro-1-phenyluracil (8) with methylhydrazine.In addition, not only the precursor of 16, 6-chloro-1-phenyluracil (8), but also other new chlorinated regioisomers of mono N-substituted pyrimidine (9) and uracil (14) were isolated and characterized by the reductive dechlorination of them.

STEREOCHEMICAL STUDIES 107; SATURATED HETEROCYCLES 111; PREPARATION OF URACILS VIA CYCLOREVERSION OF NORBORNENE-FUSED PYRIMIDINEDIONES

From diexo-norbornane- and norbornene-azetidinones 5 and 6 with aryl isocyanates, N-arylcarbamoyl-substituted β-lactams (9 and 10) were prepared.The structures of the compounds were elucidated by IR, NMR spectroscopy and X-ray analysis, in comparison with saturated methylene-bridged quinazoline-2,4-diones (7a-b) prepared from norbornane-diexo-β-amino acid (1) with isocyanates and PPA.When heated with PPA, compounds 9 can be isomerized to 7.For preparation of the unsaturated compounds 8, the amino acid 2 was converted into the acid amides (13) and cyclized with 1,1'-carbonyl-diimidazole to tricyclic quinazoline-2,4-dione (8a-e), which decompose when heated, splitting off cyclopentadiene to yield 3-substituted uracils (14).