42600-74-8Relevant academic research and scientific papers
Analyses of Synthetic N -Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype-1 (TRPV1)-Activating Properties
Pallavi, Prama,Pretze, Marc,Caballero, Julio,Li, Yingchun,Hofmann, Bj?rn B.,Stamellou, Eleni,Klotz, Sarah,W?ngler, Carmen,W?ngler, Bj?rn,Loesel, Ralf,Roth, Steffen,Theisinger, Bastian,Moerz, Handan,Binzen, Uta,Greffrath, Wolfgang,Treede, Rolf-Detlef,Harmsen, Martin C.,Kr?mer, Bernhard K.,Hafner, Mathias,Yard, Benito A.,K?lsch, Anna-Isabelle
, p. 3126 - 3137 (2018/04/23)
We studied the chemical entities within N-octanoyl dopamine (NOD) responsible for the activation of transient-receptor-potential channels of the vanilloid-receptor subtype 1 (TRPV1) and inhibition of inflammation. The potency of NOD in activating TRPV1 was significantly higher compared with those of variants in which the ortho-dihydroxy groups were acetylated, one of the hydroxy groups was omitted (N-octanoyl tyramine), or the ester functionality consisted of a bulky fatty acid (N-pivaloyl dopamine). Shortening of the amide linker (ΔNOD) slightly increased its potency, which was further increased when the carbonyl and amide groups (ΔNODR) were interchanged. With the exception of ΔNOD, the presence of an intact catechol structure was obligatory for the inhibition of VCAM-1 and the induction of HO-1 expression. Because TRPV1 activation and the inhibition of inflammation by N-acyl dopamines require different structural entities, our findings provide a framework for the rational design of TRPV1 agonists with improved anti-inflammatory properties.
Multifunctional Ag@Fe2O3 yolk-shell nanoparticles for simultaneous capture, kill, and removal of pathogen
Wei, Zhanhua,Zhou, Zijian,Yang, Meng,Lin, Chenghong,Zhao, Zhenghuan,Huang, Dengtong,Chen, Zhong,Gao, Jinhao
supporting information; scheme or table, p. 16344 - 16348 (2012/07/14)
We combined silver and iron oxide nanoparticles to make unique Ag@Fe 2O3 yolk-shell multifunctional nanoparticles by the Kirkendall effect. After the surface functionalization using glucose, the Ag@Fe2O3-Glu conjugates exhibited both high capture efficiency of bacteria and potent antibacterial activity. The Ag@Fe 2O3 yolk-shell nanostructures may offer a unique multifunctional platform for simultaneous rapid detection and capture of bacteria and safe detoxification treatment.
Substituted aryl and aralkyl amides in the treatment of parkinsonism
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, (2008/06/13)
Amides having aromatic substituents of the formula: SPC1 Wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.
