42600-75-9Relevant academic research and scientific papers
Iridium-Catalyzed Asymmetric Hydrogenation of Sterically Hindered Cyclic Imines for Enantioselective Synthesis of Tetrahydroisoquinolines
Li, Bin,Liu, Ruixia,Yang, Jing,Luo, Jingyuan,Yao, Lin,Li, Muqiong,Zheng, Xiaohui,Jiang, Ru,Nie, Huifang,Zhang, Shengyong
supporting information, p. 140 - 144 (2021/01/13)
An efficient enantioselective hydrogenation of sterically hindered cyclic imines catalyzed by the Ir-tBu-ax-Josiphos complex has been described, producing a series of useful chiral bulky tetrahydroisoquinoline analogs in high isolated yields (85-96%) with good to excellent enantioselectivities (74-99% ee). This transformation provided highly straightforward access to the useful derivatives of tetrahydroisoquinolines, which are of great potential value in drug molecule and natural product research.
Preparation method of compound 5,6-dihydroxy indoline and halogen acid salts thereof
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Paragraph 0089-0092; 0112, (2018/04/01)
The invention relates to a preparation method of a compound 5,6-dihydroxy indoline and halogen acid salts thereof. Phenylethylamine SM-0 sold in the market is used as a raw material and firstly reactswith acyl chloride to obtain amide SM-1; amide SM-1 rea
Substituted aryl and aralkyl amides in the treatment of parkinsonism
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, (2008/06/13)
Amides having aromatic substituents of the formula: SPC1 Wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.
