42600-75-9Relevant articles and documents
Iridium-Catalyzed Asymmetric Hydrogenation of Sterically Hindered Cyclic Imines for Enantioselective Synthesis of Tetrahydroisoquinolines
Li, Bin,Liu, Ruixia,Yang, Jing,Luo, Jingyuan,Yao, Lin,Li, Muqiong,Zheng, Xiaohui,Jiang, Ru,Nie, Huifang,Zhang, Shengyong
supporting information, p. 140 - 144 (2021/01/13)
An efficient enantioselective hydrogenation of sterically hindered cyclic imines catalyzed by the Ir-tBu-ax-Josiphos complex has been described, producing a series of useful chiral bulky tetrahydroisoquinoline analogs in high isolated yields (85-96%) with good to excellent enantioselectivities (74-99% ee). This transformation provided highly straightforward access to the useful derivatives of tetrahydroisoquinolines, which are of great potential value in drug molecule and natural product research.
Substituted aryl and aralkyl amides in the treatment of parkinsonism
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, (2008/06/13)
Amides having aromatic substituents of the formula: SPC1 Wherein R is an acyl radical derived from a carboxylic acid having from 3 to 20 carbon atoms, X and Y are members selected from the group consisting of hydrogen, fluoro, trifluoromethyl and hydroxy, and n is an integer selected from the group consisting of 0, 1 and 2, exhibit an effect upon the central nervous system.