42607-87-4Relevant academic research and scientific papers
INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
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Paragraph 234; 235, (2016/10/11)
The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
A chemoselective approach to grafting biodegradable polyesters
Taniguchi, Ikuo,Mayes, Anne M.,Chan, Eugene W. L.,Griffith, Linda G.
, p. 216 - 219 (2007/10/03)
The process of chemoselective coupling applied to side chains of poly(ethylene oxide) (PEO) grafted to ketone-bearing polyetsers yielding biodegradable polyesters, was investigated. Chemoselective coupling was performed by mixing the ketone-bearing PCL an
Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains
Loiseau, Francois A.,Hii, King Kuok,Hill, Alison M.
, p. 639 - 647 (2007/10/03)
A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2-CH2)nY (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.
ENCODED REACTION CASSETTE
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, (2008/06/13)
A reaction cassette has been designed for the highly sensitive detection of the making and breaking of chemical bonds. The system may be employed as a companion device to be used in the search for antibody and other novel catalysts. The cassette also has important clinical applications in the design of diagnostic reagents. In its fully encoded format this methodology is capable of both detecting and decoding chemical events.
A convenient synthetic route to differentially functionalized long chain polyethylene glycols
Burns,Field,Hashimoto,Petteys,Ridley,Samankumara Sandanayake
, p. 2337 - 2347 (2007/10/03)
A convenient and efficient synthetic route to differentially functionalized polyethylene glycols (PEGs) starting from cheap commercially available materials is reported. Selectively protected triethylene glycol or tetraethylene glycol have been reacted with a second PEG bearing both a protecting group and a leaving group.
The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface
Boden, Neville,Bushby, Richard J.,Clarkson, Steven,Evans, Stephen D.,Knowles, Peter F.,Marsh, Andrew
, p. 10939 - 10952 (2007/10/03)
Molecular tethers have been synthesised for fixing biomembranes to a gold surface. These are comprised of a thiol at one end to bind to the gold, a polyethylenoxy chain of defined length (two, six or twelve ethylenoxy units) in the middle and a cholesteryl residue at the other end to insert into the biomembrane.
