426260-72-2Relevant articles and documents
Novel lipase-catalysed highly selective acetylation studies on D-arabino- and D-threo-polyhydroxyalkyltriazoles
Prasad, Ashok K,Himanshu,Bhattacharya, Anupam,Olsen, Carl E,Parmar, Virinder S
, p. 947 - 951 (2007/10/03)
Capabilities of lipases from Candida antarctica, Candida rugosa and porcine pancreas have been evaluated for regioselective acetylation of 2-phenyl-4-(D-arabino-tetrahydroxybutyl)-2H-1,2,3-triazole, 2-phenyl-4-(D-arabino-O-1',2'-isopropylidene-3',4'-dihydroxybutyl)-2H-1,2,3-triazole and 2-phenyl-4-(D-threo-trilhydroxypropyl)-2H-1,2,3-triazole, precursors for the synthesis of triazolylacylonucleosides. C. antarctica lipase and porcine pancreatic lipase exhibited exclusive selectivity for the acetylation of primary hydroxyl group over secondary hydroxyl group(s) in all three cases. Copyright