426820-39-5Relevant articles and documents
The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
Iikubo, Kazuhiko,Ishikawa, Yuichi,Ando, Noritaka,Umezawa, Kazuo,Nishiyama, Shigeru
, p. 291 - 293 (2007/10/03)
A total synthesis of α-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3-CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingomyelinase were discussed.