426835-41-8

Usage

Appearance

Yellowish powder The compound appears as a yellowish powder, which is a common form for many organic compounds.

Molecular weight

301.34 g/mol The molecular weight of the compound is 301.34 grams per mole, which is the mass of one mole of the compound.

Derivative of benzene

The compound is derived from benzene, a common structural framework found in many organic compounds.

Nitrile functional group

The presence of a nitrile functional group (C≡N) in the compound contributes to its chemical reactivity and properties.

Potential biological activities

2-[(E)-3-(3-methoxyphenyl)prop-2-enoyl]benzene-1-carbonitrile exhibits potential biological activities, which may have applications in medicinal chemistry.

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 2142-69-0 2-bromophenyl methyl ketone 
• 544-92-3 copper(I) cyanide 
• 426835-33-8 (E)-1-(2-bromophenyl)-3-(3-methoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Cascade radical synthesis of heteroarenes via iminyl radicals

A novel cascade cyclisation protocol has been developed which 'zips up' two rings to form new tetracycles. In the protocol, treatment of vinyl bromides and iodides with hexamethylditin (Me3Sn· yields intermediate vinyl radicals which undergo 5-exo cyclisation onto nitrile groups to yield intermediate iminyl radicals. The iminyl radicals can undergo 6-endo cyclisation (or 5-exo followed by neophyl rearrangement) to yield tetracyclic π-radicals which lose hydrogen (H·) in an H-abstraction step. Methyl radicals, generated from the breakdown of trimethylstannyl radicals (Me3Sn·), are proposed as a possible H-abstractor for this final oxidative step. The protocol has been used to synthesise the tetracyclic rings A-D (tetracycle indolizino[1,2-b]quinolin-9(11H)-one) of the anticancer alkaloids camptothecin, mappicine, nothapodytine B and nothapodytine A. The protocol has also been applied to the synthesis of analogues of camptothecin in which ring A has been replaced by thiophene (8,10-dihydrothieno[2′,3′:5,6]pyrido[2,3-a]indolizin-8-one) and ring D by pyrrole (10H-pyrrolizino[1,2-b]quinoline) and benzene (11H-indeno[1,2-b]quinolin-11-one).