426840-20-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 287729-10-6 N-benzyl-N-benzoylaminophthalimide 
• 100-39-0 benzyl bromide 
• 662148-64-3 N^α-benzoyl-N^β,N^β-bis(tert-butyloxycarbonyl)hydrazine 
• 100-51-6 benzyl alcohol 
• 34387-89-8 N-(tert-butoxycarbonylamino)phthalimide 
• 870-46-2 t-butoxycarbonylhydrazine 
• 220294-77-9 N^β,N^β-[bis(tert-butoxycarbonyl)amino]phthalimide 
• 613-94-5 benzoic acid hydrazide 
• 74-89-5 methylamine 

Downstream Products

• 109396-14-7 N^α-benzoyl-N^α-benzyl-N^β-(tert-butyloxycarbonyl)hydrazine 

Relevant academic research and scientific papers

Preparation of Multiply Protected Alkylhydrazine Derivatives by Mitsunobu and PTC Approaches

Alkylation reactions of hydrazine derivatives by Mitsunobu or PTC approaches are described. It has been shown that aminophthalimide derivatives are better acidic partners than their aminoimidodicarbonate (NBoc2) analogues, the presence of the phthaloyl group increasing the acidity of the sole proton and concomitantly reducing steric hindrance. Moreover, N-aminophthalimide derivatives can be efficiently converted into the corresponding N-amino-imidodicarbonates by a three-stage, one-flask procedure under very mild conditions. These procedures can also be efficiently used for the preparation of orthogonally Nα,Nβ -diprotected α-hydrazino esters. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

Very efficient one-pot conversion of N-aminophthalimide derivatives into the corresponding N-amino-di-tert-butyl imidodicarbonates

The phthaloyl group can be efficiently converted in very mild conditions into bis-tert-butyloxycarbonyl group using MeNH2, then Boc2O/DMAP, in a one-flask protocol.