4269-98-1Relevant academic research and scientific papers
Rapid access to novel 2-alkylthiopyrimidine derivatives and attempt of their Tacrine analogs synthesis
Derabli, Chamseddine,Boulcina, Raouf,Kirsch, Gilbert,Debache, Abdelmadjid
supporting information, p. 395 - 403 (2019/01/21)
A variety of novel 2-alkylthiopyrimidines were synthesized through simple condensation of arylidenemalononitriles with different 2-alkylthiouronium halide derivatives catalyzed by anhydrous potassium carbonate (K2CO3). The reactions have been carried out under mild conditions in i-PrOH, and the products were obtained in moderate to good yields with a simple work-up method. Subsequently, some examples of these compounds have been converted into Tacrine analogs by applying the Friedl?nder reaction.
Tert -Butyl Hypochlorite Mediated Oxidative Chlorination of S -Alkylisothiourea Salts: Synthesis of Sulfonyl Chlorides
Qiu, Kui,Wang, Rennan
, p. 3186 - 3190 (2015/10/19)
Under neutral conditions, a variety of S-alkylisothiourea salts were smoothly converted into the corresponding sulfonyl chlorides through tert-butyl chlorite mediated oxidative chlorination in good to excellent yields after simple purification. In addition to the environmental and procedural advantages of this method, the neutral conditions potentially make it applicable to substrates that bear acid-sensitive functional groups. For example, the Cbz-protected 2-aminoethanesulfonyl chloride could be synthesized in moderate to good yields under the current neutral conditions, and the acid-sensitive Cbz-protecting group was not affected.
Clean and economic synthesis of alkanesulfonyl chlorides from S-alkyl isothiourea salts via bleach oxidative chlorosulfonation
Yang, Zhanhui,Zhou, Bingnan,Xu, Jiaxi
, p. 225 - 229 (2014/03/21)
A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.
A versatile one-pot synthesis of dialkyl disulfides and sulfides
Emerson, David W.,Bennett, Byron L.,Steinberg, Spencer M.
, p. 631 - 638 (2007/10/03)
Conversions of monofluoroalkyl and alkyl bromides to the corresponding dialkyl disulfides in a one-pot synthesis using thiourea followed by basic hydrogen peroxide are described. Modified methods afford access to unsymmetrical disulfides and sulfides.
Synthesis of sulfides by reactions of 1,1-dichloro-2-chloro- methylcyclopropane with S-nucleophiles
Mikhed'kina,Nedel'ko,Prezhdo
, p. 370 - 375 (2007/10/03)
1,1-Dichloro-2-chloromethylcyclopropane reacts with thiolates to give 2,2-dichlorocyclopropylmethyl sulfides via replacement of the side-chain chlorine atom. The resulting sulfides are readily oxidized to the corresponding sulfones.
Comparative Study of the 13C Nuclear Magnetic Resonance Shifts of Carbonyl and Thiocarbonyl Compounds
Katritzky, Alan R.,Sobiak, Stanislaw,Marson, Charles M.
, p. 665 - 670 (2007/10/02)
The 13C spectra of nine novel and fifteen known derivatives YC(:X)Z with X = O or S are reported and compared with literature data.Two linear relationships between 13C=O and 13C=S are established depending on whether or not Y or Z is linked through an O atom to the C=X group.General equations for 13C=O and 13C=S in terms of the attached groups are also deduced.The 13C chemical shifts of n-butyl and n-octyl groups attached to the heteroatoms in this series of compounds are recorded and discussed.
SYNTHESIS OF MONO(ALKYLTHIO)-SUBSTITUTED KETONES
Sabirov, S. S.,Gnevasheva, L. M.,Ismailov, M. I.,Isobaev, M. D.
, p. 1239 - 1243 (2007/10/02)
In the reaction of 2-propanone in the presence of sodium bicarbonate with a mixture of formaldehyde and the corresponding alkaline hydrolyzates of S-alkylthiuronium salts (thioalcoholates) β-keto sulfides (1-alkylthio-3-butanones) were obtained.Ketalization of the products with glycerol gave the cyclic derivatives alkylthio-1,3-dioxolanes.
