4276-26-0

Usage

Uses

Used in Pharmaceutical Compounds Synthesis:
(N¹-benzyl-3-indolyl)acetamide is used as a key building block in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the creation of a diverse range of biologically active molecules, contributing to the development of new drugs and treatments.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (N¹-benzyl-3-indolyl)acetamide serves as an essential component in the study and development of novel drug candidates. Its potential pharmacological properties make it a valuable tool for researchers working on drug discovery and the advancement of medical treatments.
Used in Drug Development:
(N¹-benzyl-3-indolyl)acetamide is employed in drug development as a starting material for the creation of new pharmaceutical agents. Its structural versatility and potential pharmacological activities enable the design and synthesis of innovative drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the realm of organic synthesis, (N¹-benzyl-3-indolyl)acetamide is utilized as a versatile intermediate for the preparation of a wide array of organic compounds. Its unique structure and reactivity make it a valuable asset in the synthesis of complex organic molecules for various applications, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 100-39-0 benzyl bromide 
• 104819-24-1 1-benzylindole-3-acetic chloride 
• 1912-33-0 Indole-3-acetic acid methyl ester 
• 87-51-4 indole-3-acetic acid 
• 125923-35-5 methyl (N¹-benzyl-3-indolyl)acetate 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 264619-97-8 {N¹-benzyl-N¹⁰-[6-methylthio-3-(1,2,4,5-tetrazinyl)]-3-indolyl}acetamide 

Relevant academic research and scientific papers

Effect of indole-3-acetic acid analogs on the differentiation of HL-60 cells

In continuing search for novel cell differentiation agents, a series of derivatives of indole-3-acetic acid and indole-3-carboxylic acid were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Among them, N-ethyl-1-benzylindole-3-carboxamide (14) was the most potent, whereas N-methyl 1-benzylindole-3-acetamide (5) and N-methyl 1-benzylindole-3-carboxamide (13) synergistically potentiated with all-trans-retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.

Intramolecular inverse electron demand Diels-Alder reactions of tryptamine with tethered heteroaromatic azadienes

1,2,4,5-Tetrazines and 1,2,4-triazines tethered to tryptamine via the ethylamine side chain undergo intramolecular inverse electron demand cycloadditions to produce adducts with the [ABazaCE]-ring skeleton of the Aspidosperma alkaloids. (C) 2000 Elsevier Science Ltd.

Construction of indole and benzofuran systems on the solid phase via palladium-mediated cyclizations

Molecular diversity in the area of nonpeptide, small organic molecules has been receiving considerable attention in the chemical community. Herein, we report new solid-phase methodology for the rapid generation of such small-molecule libraries by simultaneous-parallel or combinatorial synthesis. We have adapted a palladium-mediated, intramolecular Heck-type reaction, a mild and versatile method for carbon-carbon bond formation, to the solid phase. This has been applied to the synthesis of diverse indole and benzofuran derivatives, such as 8, 15, and 28, in good to excellent yields.