42797-81-9Relevant academic research and scientific papers
Intramolecular reductive ketone-alkynoate coupling reaction promoted by (η2-propene)titanium
Schaefer, Christian,Miesch, Michel,Miesch, Laurence
supporting information; scheme or table, p. 3253 - 3257 (2012/06/01)
Intramolecular reductive coupling of cycloalkanones tethered to alkynoates in the presence of (η2-propene)titanium was successfully performed to provide hydroxy-esters in a diastereoselective manner. Subsequent lactonization afforded angularly
Preparation of 5-membered rings via radical addition-translocation- cyclization (RATC) processes mediated by diethyl thiophosphites
Lamarque, Christophe,Beaufils, Florent,Denes, Fabrice,Schenk, Kurt,Renaud, Philippe
supporting information; experimental part, p. 1353 - 1358 (2011/06/26)
A practical method for the formation of thiophosphonates bearing functionalized monocyclic, fused bicyclic and spirocyclic residues is presented. The procedure requires the easily available terminal alkynes as starting materials as well as commercially an
Dimethyl phosphite mediated hydrogen atom abstraction: A tin-free procedure for the preparation of cyclopentane derivatives
Beaufils, Florent,Denes, Fabrice,Renaud, Philippe
, p. 5273 - 5275 (2007/10/03)
(Chemical Equation Presented) A radical transformation! An efficient radical cascade reaction leads to functionalized five-membered rings. Alkenyl radicals are generated from readily available terminal alkynes and a dialkyl phosphite. This tin-free proced
Thiophenol-mediated 1,5-hydrogen atom abstraction: Easy access to mono- and bicyclic compounds
Beaufils, Florent,Denes, Fabrice,Becattini, Barbara,Renaud, Philippe,Schenk, Kurt
, p. 1587 - 1594 (2007/10/03)
A thiophenol-mediated method for cyclization of alkynes is described. The reaction cascade involves the intermolecular addition of a phenylthiyl radical to a terminal triple bond generating an alkenyl radical, followed by a 1,5-hydrogen atom transfer and a 5-exo-trig radical cyclization. This very efficient tin-free procedure allows one to prepare highly functionalized cyclopentane derivatives as well as fused bicyclic and spirocyclic compounds from easily available precursors. During this cyclization process, a phenylthio moiety is incorporated into the final cyclized products. This functionalization is particularly attractive for further transformation of the products.
1,5-Hydrogen atom transfer/radical cyclization of cycloalkanones bearing a β-iodo α,β-unsaturated ester or nitrile side chain
Sha,Hsu,Chen,Cheng
, p. 9865 - 9869 (2007/10/03)
Treatment of cycloalkanones, each bearing β-iodo α,β-unsaturated ester or nitrile side chains, with tributyltin hydride and AIBN effected a 1,5-hydrogen atom transfer/radical cyclization sequence to afford the fused- or spiro-cyclic ketones. (C) 2000 Else
